PMID- 8734139
OWN - NLM
STAT- MEDLINE
DCOM- 19961017
LR  - 20131121
IS  - 0003-3928 (Print)
IS  - 0003-3928 (Linking)
VI  - 45
IP  - 2
DP  - 1996 Feb
TI  - [Evaluation of amlodipine in stable effort angina. Comparison with diltiazem in 
      terms of efficacy, tolerability and maintenance of the anti-ischemic action 24 
      hours after the last dose].
PG  - 74-82
AB  - 83 patients were enrolled in a multicentre, randomized, open study to assess the 
      efficacy of amlodipine in stable effort angina. Preselected patients were 
      submitted to a one-week placebo wash-out period during which only nitrates or 
      molsidomine were authorized. Patients were then randomized to receive either 5 mg 
      of amlodipine as a morning dose, or 180 mg of diltiazem in three divided doses. 
      After two weeks, the dosage was able to be increased (according to clinical 
      efficacy) to 10 mg of amlodipine as a single dose or 240 mg of diltiazem in four 
      divided doses. The antianginal efficacy of these two treatments was essentially 
      evaluated in terms of the results of stress tests (ST) conducted at the end of 
      the second week and fourth week of active treatment: and 24 hours after the last 
      dose of the drug. The results of 63 patients who scrupulously complied with the 
      protocol showed that amlodipine and diltiazem corrected or improved the ST 
      parameters (time to onset and amplitude of ST depression, duration of ST, work 
      performed). The anti-ischaemic action of amlodipine was maintained for at least 
      24 hours after the last dose and therefore provides better security (by covering 
      the entire 24-hour period) and better compliance (by tolerating a dose omission 
      of several hours).
FAU - Marchand, X
AU  - Marchand X
AD  - Service de Cardiologie, CHI de Poissy.
FAU - Tibi, T
AU  - Tibi T
FAU - Bernaud, C
AU  - Bernaud C
FAU - Morand, P
AU  - Morand P
LA  - fre
PT  - Clinical Trial
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
TT  - Evaluation de l'amlodipine dans l'angor d'effort stable. Comparaison avec le 
      diltiazem en termes d'efficacite, de tolerance et de maintien de l'action 
      anti-ischemique 24 heures apres la derniere prise.
PL  - France
TA  - Ann Cardiol Angeiol (Paris)
JT  - Annales de cardiologie et d'angeiologie
JID - 0142167
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Vasodilator Agents)
RN  - 1J444QC288 (Amlodipine)
RN  - EE92BBP03H (Diltiazem)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amlodipine/adverse effects/*therapeutic use
MH  - Angina Pectoris/*drug therapy/physiopathology
MH  - Blood Pressure
MH  - Calcium Channel Blockers/adverse effects/*therapeutic use
MH  - Diltiazem/adverse effects/*therapeutic use
MH  - Exercise Test
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Physical Exertion
MH  - Vasodilator Agents/adverse effects/*therapeutic use
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
PST - ppublish
SO  - Ann Cardiol Angeiol (Paris). 1996 Feb;45(2):74-82.