PMID- 8734292
OWN - NLM
STAT- MEDLINE
DCOM- 19961022
LR  - 20161031
IS  - 0003-4266 (Print)
IS  - 0003-4266 (Linking)
VI  - 57
IP  - 1
DP  - 1996
TI  - [Pancreatic somatostatinoma and MEN 1. Apropos of a case. Review of the 
      literature].
PG  - 71-6
AB  - The pancreatic somatostatinoma belongs to the type of rare endocrine tumors of 
      the pancreas. We report the observation of a 54 year old woman. Previously she 
      was suffering from diabetes mellitus. An abdominal ultrasonography revealed an 
      endocrine tumor of the pancreatic tail. There was no specific symptomatology, 
      with the exception for the hyperglycaemia. The diagnosis of somatostatinoma was 
      certified post operatively by the immunocytochemistry of the tumor. Then, the 
      patient developed a hypercalcaemia associated with an increase of parathyroid 
      hormone. The surgery of the neck revealed three hyperplastic parathyroids, 
      inducing this association as a multiple endocrine neoplasia type 1 (MEN 1). The 
      patient did not develop pituitary tumor. Afterwards, scintigraphy with 111 
      Indium- octreotide showed a residual tumor at the head of pancreas. Basal levels 
      of somatostatine and calcium, pentagastrine test, computed tomography scan, 
      arteriography were negative. The presence of a second somatostatinoma was 
      confirmed by surgery and immunohistology. One year after the surgery, the patient 
      remains clinically well. The pancreatic localization of the somatostatinoma in a 
      MEN 1 is poorly documented. Its malignant nature can only be assured by the 
      presence of metastases. The genetic detection of the MEN 1 becomes possible. 
      Above all, the treatment is based on surgery and/or chemotherapy (Fluoro-Uracile; 
      Streptozotocine). In our case, 111 In-octreotide scintigraphy was the only method 
      demonstrating a residual focus, suggesting it could be an element of reference 
      for the diagnosis and survey of somatostatinoma the watch of patients having a 
      treatment for somatostatinoma.
FAU - Roy, J
AU  - Roy J
AD  - Service de Medecine Interne, CH J. Monod, Flers.
FAU - Pompilio, M
AU  - Pompilio M
FAU - Samama, G
AU  - Samama G
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Somatostatinome pancreatique et NEM 1. A propos d'une observation. Revue de la 
      litterature.
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
SB  - IM
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis
MH  - Pancreatic Neoplasms/*complications/diagnosis/surgery
MH  - Somatostatinoma/*complications/diagnosis/surgery
RF  - 26
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Endocrinol (Paris). 1996;57(1):71-6.