PMID- 8734482
OWN - NLM
STAT- MEDLINE
DCOM- 19970305
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 35
IP  - 2
DP  - 1996 Feb
TI  - Reduction of cerebellar GABAA responses by interleukin-1 (IL-1) through an 
      indomethacin insensitive mechanism.
PG  - 147-52
AB  - Recently, a role of IL-1 in the central nervous system has been described, 
      principally a fever-inducing effect in the hypothalamus through a prostaglandin 
      second messenger system. IL-1 has also been shown to potentiate 
      gamma-aminobutyric acid (GABAA) responses in embryonic chick neurones. This study 
      describes the investigation of the effect of IL-1 on GABAA responses within the 
      in vitro rat cerebellar slice, a preparation containing intact neuronal 
      circuitry. Stimulation of the area of passage of paralleled fibres produced a 
      pure GABAA inhibition of the spontaneous firing of Purkinje cells. 5 and 10 ng/ml 
      IL-1 produced a reduction in the duration of inhibition 10 min after beginning 
      perfusion of IL-1. This effect reversed within 15 min of washing out the IL-1. 10 
      ng/ml IL-1 also reduced the effects of exogenously-applied GABA (0.1 mM) with the 
      same time course. In the presence of 1 uM indomethacin, there was no change in 
      the effect of the IL-1. It can therefore be concluded that the reduction in 
      cerebellar GABAA responses by IL-1 is not mediated by the indomethacin-sensitive 
      prostaglandin second messenger system.
FAU - Pringle, A K
AU  - Pringle AK
AD  - Department of Physiology and Pharmacology, University of Southhampton, U.K.
FAU - Gardner, C R
AU  - Gardner CR
FAU - Walker, R J
AU  - Walker RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Interleukin-1)
RN  - 0 (Receptors, GABA-A)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Cerebellum/*drug effects/physiology
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Electrophysiology
MH  - In Vitro Techniques
MH  - Indomethacin/pharmacology
MH  - Interleukin-1/*pharmacology
MH  - Male
MH  - Purkinje Cells/*drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, GABA-A/*drug effects/physiology
MH  - gamma-Aminobutyric Acid/*pharmacology
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 0028390895001611 [pii]
AID - 10.1016/0028-3908(95)00161-1 [doi]
PST - ppublish
SO  - Neuropharmacology. 1996 Feb;35(2):147-52. doi: 10.1016/0028-3908(95)00161-1.