PMID- 8735129
OWN - NLM
STAT- MEDLINE
DCOM- 19961210
LR  - 20221207
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 34
IP  - 6
DP  - 1996 Jun
TI  - Rare association of human herpesvirus 6 DNA with human papillomavirus DNA in 
      cervical smears of women with normal and abnormal cytologies.
PG  - 1589-91
AB  - We investigated by nested PCR the possible association of human herpesvirus 6 
      (HHV-6) and human papillomavirus (HPV) genomes in the cervixes of 109 women with 
      normal and abnormal cytological smears. HPV DNA was detected in 8.33% of 24 women 
      with normal cytologies and in 41.1% of 85 women with abnormal cytologies; the 
      proportion of HPV DNA was directly related to the severity of the lesions. HHV-6 
      DNA was found in only one patient, who had a cytological pattern of koilocytosis. 
      The HHV-6 genome was classified by restriction enzyme analysis as variant B. The 
      study indicates that detection of the HHV-6 genome in the cervixes of women with 
      a wide spectrum of gynecological complaints is a rare event and rules out the 
      possible association between HHV-6 and HPV genomes in cervical cancer lesions.
FAU - Romano, N
AU  - Romano N
AD  - Dipartimento di Igiene e Microbiologia G. D'Alessandro, Universita degli Studi di 
      Palermo, Italy.
FAU - Romano, F M
AU  - Romano FM
FAU - Viviano, E
AU  - Viviano E
FAU - Vitale, F
AU  - Vitale F
FAU - Villafrate, M R
AU  - Villafrate MR
FAU - Perna, A M
AU  - Perna AM
FAU - Bonura, F
AU  - Bonura F
FAU - Guttadauro, R
AU  - Guttadauro R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Cervix Uteri/cytology/pathology/*virology
MH  - Cocarcinogenesis
MH  - DNA, Viral/*genetics/*isolation & purification
MH  - Female
MH  - Herpesvirus 6, Human/*genetics/*isolation & purification/pathogenicity
MH  - Humans
MH  - Middle Aged
MH  - Papillomaviridae/*genetics/*isolation & purification/pathogenicity
MH  - Polymerase Chain Reaction
MH  - Uterine Cervical Neoplasms/etiology/virology
MH  - Vaginal Smears
MH  - Uterine Cervical Dysplasia/etiology/virology
PMC - PMC229073
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
PMCR- 1996/06/01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
PHST- 1996/06/01 00:00 [pmc-release]
AID - 10.1128/jcm.34.6.1589-1591.1996 [doi]
PST - ppublish
SO  - J Clin Microbiol. 1996 Jun;34(6):1589-91. doi: 10.1128/jcm.34.6.1589-1591.1996.