PMID- 8736095
OWN - NLM
STAT- MEDLINE
DCOM- 19970107
LR  - 20190516
IS  - 0074-0276 (Print)
IS  - 0074-0276 (Linking)
VI  - 91
IP  - 2
DP  - 1996 Mar-Apr
TI  - Tumor necrosis factor-alpha in human american tegumentary leishmaniasis.
PG  - 225-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced by activated 
      macrophages and other cells. In order to verify whether the serum levels of 
      TNF-alpha in American tegumentary leishmaniasis patients are associated with the 
      process of cure or aggravation of the disease, 41 patients were studied: 26 cases 
      of cutaneous leishmaniasis (CL) and 15 of mucocutaneous leishmaniasis (MCL). 
      During active disease the serum levels of TNF-alpha of MCL patients were 
      significantly higher than those of CL patients and control subjects (healthy 
      individuals and cutaneous lesions from other etiologies). The MCL patients had 
      serum titers of TNF-alpha significantly lower at the end of antimonial therapy 
      than before therapy. After a six-month follow-up, the MCL patients had serum 
      levels of TNF-alpha similar to those observed at the end of the therapy as well 
      as to those of CL patients and control subjects. No significant variation in the 
      serum levels of TNF-alpha was observed in CL patients throughout the study period 
      (before, at the end of therapy and after a six-month follow-up). The possible 
      relationship between the high TNF-alpha serum levels and severity of the disease 
      is discussed.
FAU - Da-Cruz, A M
AU  - Da-Cruz AM
AD  - Departamento de Protozoologia, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, 
      Brasil.
FAU - de Oliveira, M P
AU  - de Oliveira MP
FAU - De Luca, P M
AU  - De Luca PM
FAU - Mendonca, S C
AU  - Mendonca SC
FAU - Coutinho, S G
AU  - Coutinho SG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antigens, Protozoan/blood
MH  - Follow-Up Studies
MH  - Humans
MH  - Leishmania braziliensis/immunology
MH  - Leishmaniasis, Cutaneous/*immunology
MH  - Middle Aged
MH  - Skin Tests
MH  - Tumor Necrosis Factor-alpha/analysis/*physiology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - S0074-02761996000200019 [pii]
AID - 10.1590/s0074-02761996000200019 [doi]
PST - ppublish
SO  - Mem Inst Oswaldo Cruz. 1996 Mar-Apr;91(2):225-9. doi: 
      10.1590/s0074-02761996000200019.