PMID- 8738408
OWN - NLM
STAT- MEDLINE
DCOM- 19961202
LR  - 20220318
IS  - 0724-4983 (Print)
IS  - 0724-4983 (Linking)
VI  - 14 Suppl 1
DP  - 1996
TI  - Extracellular matrix and integrin composition of the normal bladder wall.
PG  - S30-7
AB  - We performed an immunohistochemistry study of the normal human bladder so as to 
      understand the interactions of extracellular matrix (ECM) components and the 
      integrins of cell adhesion that accommodate the volume changes and maintain an 
      impermeable barrier to reabsorption of urine in the bladder. The normal human 
      urothelial cell and/or its plasma membrane contained integrins alpha 3, alpha V, 
      beta 1, and beta 4 but did not contain integrin beta 3. The urothelial basement 
      membrane (UBM) contained collagen type IV and laminin. Fibronectin and integrins 
      alpha 3 and beta 4 were found in or near the UBM area, with types I and III 
      collagen and tenascin abutting the area. The patterns of collagen, laminin, 
      tenascin, vitronectin, fobronectin, and the alpha 3, alpha V, beta 1, and beta 3 
      integrins in the lamina propria, vessels, nerves, and smooth-muscle layers are 
      described. These findings detail the normal anatomical ECM/integrin relationship 
      that provides the cellular basis for bladder-wall relationships responsible for 
      its impermeable state and other functions.
FAU - Wilson, C B
AU  - Wilson CB
AD  - Department of Immunology, Scripps Research Institute, La Jolla, California 
      92037-1093, USA.
FAU - Leopard, J
AU  - Leopard J
FAU - Cheresh, D A
AU  - Cheresh DA
FAU - Nakamura, R M
AU  - Nakamura RM
LA  - eng
GR  - DK 42717/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - World J Urol
JT  - World journal of urology
JID - 8307716
RN  - 0 (Integrins)
SB  - IM
MH  - Cells, Cultured
MH  - Extracellular Matrix/chemistry/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Integrins/chemistry/*metabolism
MH  - Reference Values
MH  - Urinary Bladder/cytology/*metabolism
MH  - Urinary Bladder Neoplasms/*metabolism/pathology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF00182062 [doi]
PST - ppublish
SO  - World J Urol. 1996;14 Suppl 1:S30-7. doi: 10.1007/BF00182062.