PMID- 8738604
OWN - NLM
STAT- MEDLINE
DCOM- 19961002
LR  - 20190905
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 39
IP  - 1
DP  - 1996
TI  - MMTV-induced mutations in mouse mammary tumors: their potential relevance to 
      human breast cancer.
PG  - 33-44
AB  - In mouse mammary tumor virus (MMTV) infected mice, three identifiable stages of 
      mammary tumorigenesis can be biologically defined: preneoplastic hyperplastic 
      nodules, malignant tumor, and distant metastatic lesions (primarily in the lung). 
      MMTV is a biological carcinogen which induces somatic mutations as consequence of 
      its integration into the host cellular genome. Each stage of mammary 
      tumorigenesis appears to result from the clonal outgrowth of cells containing 
      additional integrated proviral MMTV genomes. This phenomenon has provided the 
      basis for an approach to identify genes which, when affected, may contribute to 
      progression through the different stages of mammary tumorigenesis. Eight 
      different genes (Wnt1, Wnt3, Wnt10b, Fgf3, Fgf4, Fgf8, Int3, and Int6) have been 
      shown to be genetically altered in multiple mammary tumors as a consequence of 
      MMTV integration. Although the significance of the human homologs of these genes 
      as targets for somatic mutation during human breast carcinogenesis is only now 
      being explored, it is clear that this work has led to a new appreciation of the 
      complexity of the genetic circuitry that is involved in the control of normal 
      mammary gland growth and development. It seems likely that some of the mutations 
      induced by MMTV, and the signaling pathways in which these target genes take 
      part, will be relevant to the progression from preneoplastic lesions to distant 
      metastasis in human breast cancer.
FAU - Callahan, R
AU  - Callahan R
AD  - Oncogenetics Section, Laboratory of Tumor Immunology and Biology, National Cancer 
      Institute, Bethesda, Maryland 20892, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
SB  - IM
MH  - Animals
MH  - Animals, Wild
MH  - Breast Neoplasms/genetics
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Mammary Neoplasms, Experimental/*genetics/virology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Transgenic
MH  - Mutagenesis, Insertional/*genetics
MH  - Research
MH  - Retroviridae Infections/*genetics/virology
MH  - Tumor Virus Infections/*genetics/virology
RF  - 82
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF01806076 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 1996;39(1):33-44. doi: 10.1007/BF01806076.