PMID- 8739083
OWN - NLM
STAT- MEDLINE
DCOM- 19961031
LR  - 20190905
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 38
IP  - 3
DP  - 1996
TI  - A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of 
      the high mobility group protein gene family.
PG  - 299-303
AB  - An intracanalicular fibroadenoma of the breast showing a clonal chromosomal 
      aberration t(4;12) (q27;q15) as the sole cytogenetic abnormality is described. In 
      order to narrow down the breakpoint region on chromosome 12 on the molecular 
      level we performed fluorescence in situ hybridization (FISH) analysis with a 
      cosmid pool originating from a YAC-contig overspanning part of the region 
      12q14-15. We were able to narrow down the breakpoint to an approximately 230kb 
      fragment belonging to the HMGI-C gene which maps within an area recently 
      designated as MAR (Multiple Aberration Region). The chromosomal breakpoints of 
      other frequent benign solid tumors, i.e. lipomas, uterine leiomyomas, and 
      pleomorphic adenomas are clustered within the third intron of that gene.
FAU - Staats, B
AU  - Staats B
AD  - Center for Human Genetics and Genetic Counselling, University of Bremen, Germany.
FAU - Bonk, U
AU  - Bonk U
FAU - Wanschura, S
AU  - Wanschura S
FAU - Hanisch, P
AU  - Hanisch P
FAU - Schoenmakers, E F
AU  - Schoenmakers EF
FAU - Van de Ven, W J
AU  - Van de Ven WJ
FAU - Bartnitzke, S
AU  - Bartnitzke S
FAU - Bullerdiek, J
AU  - Bullerdiek J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (HMGA2 Protein)
RN  - 0 (High Mobility Group Proteins)
SB  - IM
MH  - Adolescent
MH  - Breast Neoplasms/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 4/*genetics
MH  - Female
MH  - Fibroadenoma/*genetics/ultrastructure
MH  - HMGA2 Protein
MH  - High Mobility Group Proteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Translocation, Genetic
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/BF01806149 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 1996;38(3):299-303. doi: 10.1007/BF01806149.