PMID- 8740460
OWN - NLM
STAT- MEDLINE
DCOM- 19961106
LR  - 20191024
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 12
IP  - 1
DP  - 1996 Apr
TI  - Butylated hydroxyanisole blocks the inhibitory effects of tumor necrosis 
      factor-alpha on collagen production in human dermal fibroblasts.
PG  - 44-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been demonstrated to selectively 
      decrease the production of type I and type III collagens in human dermal 
      fibroblasts. The effects of the commonly used food antioxidants, butylated 
      hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, propyl 
      gallate, superoxide dismutase (SOD), and catalase on TNF-alpha-induced growth 
      enhancement and collagen metabolism were evaluated in the present study. BHA at 
      concentrations of both 5 x 10(-5) and 10(-4) M inhibited cell proliferation and 
      DNA synthesis induced by 10 ng/ml TNF-alpha in human dermal fibroblasts, while 
      other antioxidants had minimal effects. Further, BHA (5 x 10(-5) M and 10(-4) M) 
      significantly blocked TNF-alpha-induced decreases in collagen synthesis. These 
      results suggest that antioxidants such as BHA may be involved in the modulation 
      of collagen synthesis by TNF-alpha in human dermal fibroblasts.
FAU - Taniguchi, S
AU  - Taniguchi S
AD  - Department of Dermatology, Osaka City University Medical School, Japan.
FAU - Furukawa, M
AU  - Furukawa M
FAU - Kono, T
AU  - Kono T
FAU - Hisa, T
AU  - Hisa T
FAU - Ishii, M
AU  - Ishii M
FAU - Hamada, T
AU  - Hamada T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Antioxidants)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1406-18-4 (Vitamin E)
RN  - 25013-16-5 (Butylated Hydroxyanisole)
RN  - 8D4SNN7V92 (Propyl Gallate)
RN  - 9007-34-5 (Collagen)
RN  - 9007-49-2 (DNA)
RN  - EC 1.11.1.6 (Catalase)
SB  - IM
MH  - Antioxidants/*pharmacology
MH  - Butylated Hydroxyanisole/*pharmacology
MH  - Catalase/pharmacology
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Collagen/*biosynthesis
MH  - DNA/biosynthesis
MH  - Fibroblasts/cytology/drug effects/metabolism
MH  - Humans
MH  - Propyl Gallate/pharmacology
MH  - Skin/cytology/*drug effects/*metabolism
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors/pharmacology
MH  - Vitamin E/pharmacology
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 0923181195004637 [pii]
AID - 10.1016/0923-1811(95)00463-7 [doi]
PST - ppublish
SO  - J Dermatol Sci. 1996 Apr;12(1):44-9. doi: 10.1016/0923-1811(95)00463-7.