PMID- 8741079
OWN - NLM
STAT- MEDLINE
DCOM- 19961121
LR  - 20190830
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 243
IP  - 5
DP  - 1996 May
TI  - Diversity of intrathecal antibody synthesis against HTLV-I and its relation to 
      HTLV-I associated myelopathy.
PG  - 393-400
AB  - The humoral immune response against human T-cell lymphotropic virus type I 
      (HTLV-I) in the central nervous system (CNS) compartment and in the blood was 
      investigated by enzyme immunoassay using 16 synthetic peptides corresponding to 
      HTLV-I core and envelope sequences. We evaluated paired samples of cerebrospinal 
      fluid and serum from HTLV-I seropositive Japanese patients, classified as 
      follows: HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP; n = 
      39), patients with spinal cord disease ascribed to either HAM/TSP or to some 
      concomitant, HTLV-I-unrelated disease (possible HAM/TSP; n = 6) or carriers 
      without any clinical signs of HAM/TSP (n = 15). HTLV-I-peptide-specific 
      intrathecal antibody synthesis was found in 79% of HAM/TSP patients, but only in 
      20% of carriers without HAM/TSP. The group of carriers without HAM/TSP showed 
      local synthesis for some peptides (on average 0.3 peptides per patient). In most 
      HAM/TSP patients, however, there was a diverse intrathecal immune response to 
      several HTLV-I synthetic peptides (on average against 3.6 peptides per HAM/TSP 
      patient), most frequently against gag p19 100-130, env gp21 458-488, and env gp46 
      175-199 and 288-317. The intrathecal antibody synthesis against several HTLV-I 
      determinants may represent a pathogenic immune response in HAM/TSP and is 
      possibly related to the infiltration of virus-infected T-cells in the spinal 
      cord.
FAU - Kitze, B
AU  - Kitze B
AD  - Department of Neurology, Gottingen University, Germany.
FAU - Usuku, K
AU  - Usuku K
FAU - Izumo, S
AU  - Izumo S
FAU - Nakamura, M
AU  - Nakamura M
FAU - Shiraki, H
AU  - Shiraki H
FAU - Ijichi, S
AU  - Ijichi S
FAU - Yashiki, S
AU  - Yashiki S
FAU - Fujiyoshi, T
AU  - Fujiyoshi T
FAU - Sonoda, S
AU  - Sonoda S
FAU - Osame, M
AU  - Osame M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (Antibodies, Viral)
RN  - 0 (Gene Products, gag)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Peptides)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antibodies, Viral/blood/*cerebrospinal fluid
MH  - Antibody Formation
MH  - Antibody Specificity
MH  - Case-Control Studies
MH  - Evaluation Studies as Topic
MH  - Gene Products, gag/immunology
MH  - Human T-lymphotropic virus 1/*immunology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin G/blood/*cerebrospinal fluid
MH  - Molecular Sequence Data
MH  - Paraparesis, Tropical Spastic/blood/cerebrospinal fluid/*immunology
MH  - Peptides/*immunology
MH  - Viral Envelope Proteins/immunology
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1007/BF00868998 [doi]
PST - ppublish
SO  - J Neurol. 1996 May;243(5):393-400. doi: 10.1007/BF00868998.