PMID- 8743163
OWN - NLM
STAT- MEDLINE
DCOM- 19960913
LR  - 20190914
IS  - 1031-3613 (Print)
IS  - 1031-3613 (Linking)
VI  - 7
IP  - 6
DP  - 1995
TI  - Decidua and placenta in mice after treatment with a synthetic glucocorticoid.
PG  - 1551-5
AB  - To investigate a possible long-term effect of glucocorticoids on decidua and 
      placenta of mice, a single dose of 24 mg kg-1 body weight triamcinolone acetonide 
      in crystalline suspension was given subcutaneously to NMRI mice on gestational 
      day (GD) 2. Deciduae and placentae, as well as corticosterone and triamcinolone 
      concentrations in maternal plasma of GDs 10 and 17 were examined. 
      NADPH-cytochrome P450 reductase involved in drug biotransformation was detected 
      immunocytochemically and showed co-localization with NADPH diaphorase 
      histochemistry in the decidua and placenta. Both reactions were higher in 
      endothelial cells of decidual sinusoids on GD 10, but were lower on GD 17 in the 
      trophoblast, spongiotrophoblast and extraplacental visceral yolk-sac epithelial 
      cells of treated mice than in untreated animals. Histochemistry of 11 
      beta-hydroxysteroid dehydrogenase, an enzyme that metabolizes biologically active 
      adrenocortical steroids and their synthetic congeners in the placenta, showed 
      higher activity on GD 17 in enlarged labyrinthic trophoblast I cells of treated 
      mice than in untreated animals. As corticosterone concentrations were still 
      decreased on GD 17, when triamcinolone concentrations were no longer detectable, 
      a long-term suppression of adrenal gland function seems obvious.
FAU - Matejevic, D
AU  - Matejevic D
AD  - Institut fur Anatomie, Freie Universitat Berlin, Germany.
FAU - Heilmann, P
AU  - Heilmann P
FAU - Schuster, C
AU  - Schuster C
FAU - Schoneshofer, M
AU  - Schoneshofer M
FAU - Graf, R
AU  - Graf R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Reprod Fertil Dev
JT  - Reproduction, fertility, and development
JID - 8907465
RN  - 1ZK20VI6TY (Triamcinolone)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - EC 1.6.2.4 (NADPH-Ferrihemoprotein Reductase)
RN  - EC 1.6.99.1 (NADPH Dehydrogenase)
RN  - F446C597KA (Triamcinolone Acetonide)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Animals
MH  - Corticosterone/blood
MH  - Decidua/anatomy & histology/*drug effects/enzymology
MH  - Endothelium/metabolism
MH  - Female
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/metabolism
MH  - Mice
MH  - NADPH Dehydrogenase/metabolism
MH  - NADPH-Ferrihemoprotein Reductase/metabolism
MH  - Placenta/anatomy & histology/*drug effects/enzymology
MH  - Pregnancy
MH  - Triamcinolone/blood
MH  - Triamcinolone Acetonide/*pharmacology
MH  - Trophoblasts/enzymology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1071/rd9951551 [doi]
PST - ppublish
SO  - Reprod Fertil Dev. 1995;7(6):1551-5. doi: 10.1071/rd9951551.