PMID- 8743519
OWN - NLM
STAT- MEDLINE
DCOM- 19961120
LR  - 20131121
IS  - 0098-6577 (Print)
IS  - 0098-6577 (Linking)
VI  - 55
DP  - 1996 Jun
TI  - Nitrendipine and enalapril in the treatment of diabetic hypertensive patients 
      with microalbuminuria.
PG  - S85-7
AB  - A trial to study the efficacy, safety and tolerability of nitrendipine and 
      enalapril in the treatment of diabetic hypertensive patients with 
      microalbuminuria (MA) was performed to compare the effects of both drugs in the 
      prevention of the renal impairment. Twenty-eight valid patients [13 with 
      nitrendipine (N) and 15 with enalapril (E) with NIDDM, hypertension (diastolic 
      blood pressure between 90 to 114 mm Hg) and MA (urinary albumin between 30 to 300 
      mg/24 hr) were recruited in a double blind, randomized trial. Following a placebo 
      run-in period of two to four weeks, all eligible patients were randomly allocated 
      to either N or E treatment. Treatment lasted six months, with two different 
      visits at three and six months in which blood pressure (BP), heart rate (HR), 
      renal function and MA were measured. No statistically significant differences on 
      BP and metabolic parameters were found between both treatment groups. The 
      geometric mean of final glomerular filtration rate (GFR) in the N group was 34.5% 
      higher than in the E group, while the reduction on MA was most important in the E 
      group. Eleven patients reported adverse events (AEs) and there were four 
      dropouts, three of them due to AEs. We conclude that both treatments are a good 
      choice for treating diabetic hypertensive patients with early altered renal 
      function, as they reduce BP without altering metabolic parameters, increase GFR 
      and reduce MA with a low frequency of AEs.
FAU - Pinol, C
AU  - Pinol C
AD  - Hospital Clinic i Provincial, Hospitals Comarcals de Catalunya, Barcelona, Spain.
FAU - Cobos, A
AU  - Cobos A
FAU - Cases, A
AU  - Cases A
FAU - Esmatges, E
AU  - Esmatges E
FAU - Soler, J
AU  - Soler J
FAU - Closas, J
AU  - Closas J
FAU - Pascual, R
AU  - Pascual R
FAU - Planas, J
AU  - Planas J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Kidney Int Suppl
JT  - Kidney international. Supplement
JID - 7508622
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Blood Glucose)
RN  - 0 (Calcium Channel Blockers)
RN  - 69PN84IO1A (Enalapril)
RN  - 9B627AW319 (Nitrendipine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/etiology
MH  - Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/drug effects
MH  - Calcium Channel Blockers/adverse effects/*therapeutic use
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/prevention & control
MH  - Double-Blind Method
MH  - Enalapril/adverse effects/*therapeutic use
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hypertension/*drug therapy/etiology/urine
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Nitrendipine/adverse effects/*therapeutic use
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
PST - ppublish
SO  - Kidney Int Suppl. 1996 Jun;55:S85-7.