PMID- 8743641
OWN - NLM
STAT- MEDLINE
DCOM- 19961107
LR  - 20191101
IS  - 1040-1237 (Print)
IS  - 1040-1237 (Linking)
VI  - 8
IP  - 1
DP  - 1996 Mar
TI  - EEG abnormalities before clozapine therapy predict a good clinical response to 
      clozapine.
PG  - 1-5
AB  - The purpose of this study was to test the hypothesis that minor EEG abnormalities 
      predict a favorable response to clozapine. Eighty-six psychotic clozapine-treated 
      psychiatric inpatients with EEG records before starting clozapine were included 
      in the study. When all diagnostic groups were combined, there were no significant 
      differences in clinical outcome between patients with abnormal EEGs and patients 
      with normal EEGs. However, female patients with abnormal EEGs had a significantly 
      greater improvement in Global Assessment of Functioning (GAF) scores compared to 
      female patients with normal EEGs. In addition, patients with major depressive 
      episodes (bipolar, schizoaffective, unipolar) and abnormal EEGs had a 
      significantly greater improvement in GAF scores compared to the same subgroup of 
      patients with normal EEGs. The results suggest that EEG abnormalities before 
      clozapine treatment many predict a favorable clinical response in specific groups 
      of patients.
FAU - Pillay, S S
AU  - Pillay SS
AD  - Psychopharmacology Service, McLean Hospital, Belmont, Massachusetts 02178, USA.
FAU - Stoll, A L
AU  - Stoll AL
FAU - Weiss, M K
AU  - Weiss MK
FAU - Tohen, M
AU  - Tohen M
FAU - Zarate, C A Jr
AU  - Zarate CA Jr
FAU - Banov, M D
AU  - Banov MD
FAU - Cole, J O
AU  - Cole JO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Psychiatry
JT  - Annals of clinical psychiatry : official journal of the American Academy of 
      Clinical Psychiatrists
JID - 8911021
RN  - 0 (Antipsychotic Agents)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Bipolar Disorder/*drug therapy/physiopathology
MH  - Clozapine/*therapeutic use
MH  - Depressive Disorder/*drug therapy/physiopathology
MH  - Electroencephalography/*drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*drug therapy/physiopathology
MH  - Retrospective Studies
MH  - Schizophrenia/drug therapy/physiopathology
MH  - Sex Factors
MH  - Single-Blind Method
MH  - Treatment Outcome
EDAT- 1996/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.3109/10401239609149083 [doi]
PST - ppublish
SO  - Ann Clin Psychiatry. 1996 Mar;8(1):1-5. doi: 10.3109/10401239609149083.