PMID- 8745143
OWN - NLM
STAT- MEDLINE
DCOM- 19961011
LR  - 20041117
IS  - 0956-523X (Print)
IS  - 0956-523X (Linking)
VI  - 5
IP  - 4
DP  - 1995 Dec
TI  - Immunohistochemical localization of insulin-like growth factor-II in the 
      perinatal rat gonad.
PG  - 185-89
AB  - To clarify the participation of insulin-like growth factor type-II (IGF-II) in 
      rat gonadal differentiation, immunohistochemical localization of IGF-II was 
      chronologically studied in Sprague-Dawley rat gonads from gestational day (GD) 13 
      to postnatal day (PD) 21 by using avidin-biotin complex technique. In male 
      gonads, most cells were negative to IGF-II immunostaining during the perinatal 
      period. Only Leydig/interstitial cells expressed positive reactivity from GD 21 
      to PD 11: the intensity of staining and the number of positive cells were 
      gradually increased until PD 11. In female gonads, almost all cells showed 
      negative immunoreactivity. Mesonephric tubules in both sexes exhibited slight or 
      moderate reactivity on GD 13. These results indicate that IGF-II is likely to 
      participate in the regression of fetal-type Leydig cells and/or the proliferation 
      of adult-type Leydig cells around birth, and in the development of mesonephric 
      tubules in the initial stage of gonadal differentiation.
FAU - Koike, S
AU  - Koike S
AD  - Department of Regulation Biology, Saitama University, Japan.
FAU - Noumura, T
AU  - Noumura T
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - Growth Regul
JT  - Growth regulation
JID - 9106990
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunoglobulin G)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Monoclonal
MH  - Female
MH  - Fetus
MH  - Granulosa Cells/cytology
MH  - Immunoglobulin G
MH  - Immunohistochemistry/methods
MH  - Insulin-Like Growth Factor II/*analysis/biosynthesis
MH  - Leydig Cells/cytology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C/immunology
MH  - Ovary/*cytology/embryology/growth & development
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sensitivity and Specificity
MH  - Sertoli Cells/cytology
MH  - Sexual Maturation
MH  - Testis/*cytology/embryology/growth & development
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
PST - ppublish
SO  - Growth Regul. 1995 Dec;5(4):185-89.