PMID- 8745144
OWN - NLM
STAT- MEDLINE
DCOM- 19961011
LR  - 20071114
IS  - 0956-523X (Print)
IS  - 0956-523X (Linking)
VI  - 5
IP  - 4
DP  - 1995 Dec
TI  - Characterization of the insulin-like growth factor (IGF) axis in the serum of 
      maternal and fetal macaques (Macaca mulatta and Macaca fascicularis).
PG  - 190-8
AB  - The insulin-like growth factors (IGFs) are key effectors of fetal growth and 
      development which are modulated by serum carrier proteins (IGF binding proteins 
      [IGFBPs]). Studies were performed to evaluate the developmental profile of IGFs 
      and IGFBPs in the macaque, an important nonhuman primate model for human 
      development and disease. IGF-I, IGF-II, and IGFBP-3 were studied in the rhesus 
      (Macaca mulatta) and long-tailed (Macaca fascicularis) monkey fetus and dam 
      during the second and third trimesters of pregnancy. Serial fetal blood samples 
      were collected by cardiocentesis every 10 days from gestational day (GD) 90-160, 
      and at 1 month postnatal age; maternal blood samples were collected at similar 
      timepoints. Results indicated that maternal sera IGF-I and IGF-II did not change 
      significantly whereas fetal concentrations of serum IGF-I and IGF-II increased 
      approximately two-fold during the second to the third trimesters. No significant 
      differences were detected between the two species. Western-ligand blot analysis 
      revealed predominant IGFBPs of 45-40 (IGFBP-3) and 28 kDa (IGFBP-1) in both the 
      maternal and fetal compartments, and Western-immunoblot analysis using a specific 
      antisera against IGFBP-3 indicated 45-40 and 28 kDa immunoreactive forms. Thus, 
      although IGF-I, IGF-II, and IGFBP-3 remained relatively unaffected in maternal 
      sera during this period of gestation, fetal concentrations of IGF-I, IGF-II, and 
      IGFBP-3 increased in a developmental profile similar to the human fetus.
FAU - Tarantal, A F
AU  - Tarantal AF
AD  - California Regional Primate Research Center, University of California, Davis, 
      USA.
FAU - Gargosky, S E
AU  - Gargosky SE
LA  - eng
GR  - AI32299 RR00169/AI/NIAID NIH HHS/United States
GR  - HD25528/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Scotland
TA  - Growth Regul
JT  - Growth regulation
JID - 9106990
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Bone and Bones/embryology
MH  - *Embryonic and Fetal Development
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Gestational Age
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/analysis/*metabolism
MH  - Insulin-Like Growth Factor II/analysis/*metabolism
MH  - Macaca fascicularis
MH  - Macaca mulatta
MH  - Pregnancy
MH  - Pregnancy, Animal/*blood
MH  - Species Specificity
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
PST - ppublish
SO  - Growth Regul. 1995 Dec;5(4):190-8.