PMID- 8745169
OWN - NLM
STAT- MEDLINE
DCOM- 19961023
LR  - 20190826
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 26
IP  - 8
DP  - 1995 Dec
TI  - Effects of adenosine analogues on apomorphine-induced penile erection in rats.
PG  - 1785-90
AB  - 1. In the present work, the effect of adenosine agonists and antagonists on 
      apomorphine-induced penile erection (PE) has been studied. 2. Subcutaneous (s.c.) 
      injection of the nonselective D1/D2 dopamine receptor agonist apomorphine 
      (0.05-0.5 mg/kg) induced PE in a biphasic manner. The maximum effect was obtained 
      with 0.1 mg/kg of the drug. The response decreased with increasing doses of 
      apomorphine, from 0.1 to 0.5 mg/kg. 3. Intraperitoneal (i.p.) injections of 
      adenosine agonists 5'-N-ethylcarboxamidoadenosine (NECA) and 
      N6-cyclohexyladenosine (CHA) decreased the response of apomorphine. 
      Apomorphine-induced PE was increased by low doses (25, 50 mg/kg, i.p.) and 
      decreased by high doses (75, 100 mg/kg, i.p.) of the adenosine antagonist 
      theophylline, respectively. Inhibition of PE induced by NECA and CHA was 
      antagonized by 8-PT pretreatment. 4. Intracerebroventricular (i.c.v.) 
      administration of CHA, NECA, and theophylline produced the same effects as i.p. 
      injections of these agents on PE responses. It is concluded that A-1 and A-2 
      adenosine receptor activation may inhibit PE induced by dopaminergic 
      mechanism(s), which can be prevented by 8-PT pretreatment.
FAU - Sharifzadeh, M
AU  - Sharifzadeh M
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Iran.
FAU - Zarrindast, M R
AU  - Zarrindast MR
FAU - Samini, M
AU  - Samini M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Receptors, Purinergic P1)
RN  - 35920-39-9 (Adenosine-5'-(N-ethylcarboxamide))
RN  - 36396-99-3 (N(6)-cyclohexyladenosine)
RN  - C137DTR5RG (Theophylline)
RN  - E6M543P3BL (8-phenyltheophylline)
RN  - K72T3FS567 (Adenosine)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - Adenosine/analogs & derivatives/pharmacology
MH  - Adenosine-5'-(N-ethylcarboxamide)
MH  - Animals
MH  - Apomorphine/*pharmacology
MH  - Male
MH  - Penile Erection/*drug effects
MH  - Rats
MH  - Receptors, Purinergic P1/*drug effects/physiology
MH  - Theophylline/analogs & derivatives/pharmacology
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 030636239500114X [pii]
AID - 10.1016/0306-3623(95)00114-x [doi]
PST - ppublish
SO  - Gen Pharmacol. 1995 Dec;26(8):1785-90. doi: 10.1016/0306-3623(95)00114-x.