PMID- 8745457
OWN - NLM
STAT- MEDLINE
DCOM- 19960913
LR  - 20151119
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 30
IP  - 4
DP  - 1995
TI  - [Expression of proliferating cell nuclear antigen (PCNA) in premalignant lesions 
      of laryngeal epithelium].
PG  - 206-8
AB  - It is important to study the proliferative activity of cells in the premalignant 
      lesions of laryngeal epithelium. Using PC-10, an antibody to PCNA and a standard 
      immunohistochemical staining, we examined 11 cases of simple hyperplasia of 
      epithelium (SHE), 32 cases of atypical hyperplasia of epithelium (AHE) and 42 
      cases of laryngeal squamous cell carcinoma (LSCC) for expression of PCNA, a 
      protein associated with DNA polymerase delta and DNA replication. The results 
      revealed that the PCNA indices in SHE, AHE and LSCC were 9.57%, 27.33% and 
      68.05%, respectively. The PCNA indices were 13.79%, 30.84% and 39.94%, in the 
      mild, moderate and severe AHE, respectively. There were significant differences 
      among the SHE, AHE and LSCC. A good correlation was found among different degrees 
      of AHE. The pattern and location of PCNA positive cells in the intraepithelium 
      had diagnostic importance. PCNA might provide a useful tool for studying cell 
      proliferation in situ under normal and pathological conditions.
FAU - Zhou, G
AU  - Zhou G
AD  - First Hospital, West China University of Medical Sciences, Chengdu.
FAU - Lin, D
AU  - Lin D
FAU - Liang, C
AU  - Liang C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Epithelium/pathology
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Precancerous Conditions/pathology
MH  - Proliferating Cell Nuclear Antigen/*analysis
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 1995;30(4):206-8.