PMID- 8746342
OWN - NLM
STAT- MEDLINE
DCOM- 19961021
LR  - 20071114
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 134
IP  - 2
DP  - 1996 Feb
TI  - No detection of HTLV-I proviral DNA in lesional skin biopsies from Swiss and 
      German patients with cutaneous T-cell lymphoma.
PG  - 282-4
AB  - The search for an infective agent linked to cutaneous T-cell lymphoma (CTCL) has 
      also included the human T-cell lymphotropic virus type I (HTLV-I). Using 
      sensitive techniques such as Southern blotting under low stringency conditions of 
      hybridization and polymerase chain reaction (PCR) with primer sets designed to 
      match pol, env and pX sequences of HTLV-I, we have screened lesional skin 
      biopsies of 50 Swiss and German patients suffering from CTCL. No evidence of 
      proviral integration of HTLV-I could be demonstrated in any of our patients. Our 
      results, as well as a review of the literature, indicate that at least for 
      European patients, HTLV-I does not seem to play a role in the aetiology of CTCL.
FAU - Boni, R
AU  - Boni R
AD  - Department of Dermatology, University Hospital of Zurich, Switzerland.
FAU - Davis-Daneshfar, A
AU  - Davis-Daneshfar A
FAU - Burg, G
AU  - Burg G
FAU - Fuchs, D
AU  - Fuchs D
FAU - Wood, G S
AU  - Wood GS
LA  - eng
GR  - AR 39750/AR/NIAMS NIH HHS/United States
GR  - AR 40844/AR/NIAMS NIH HHS/United States
GR  - CA 60014/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Base Sequence
MH  - Blotting, Southern
MH  - DNA, Viral/*analysis
MH  - Germany
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Lymphoma, T-Cell, Cutaneous/*virology
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Proviruses/genetics/*isolation & purification
MH  - Skin Neoplasms/*virology
MH  - Switzerland
RF  - 20
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
PST - ppublish
SO  - Br J Dermatol. 1996 Feb;134(2):282-4.