PMID- 8747107
OWN - NLM
STAT- MEDLINE
DCOM- 19961009
LR  - 20190905
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 9
IP  - 6
DP  - 1995 Dec
TI  - Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic 
      purpura.
PG  - 694-9
AB  - Serum and urine cytokines were analyzed in children with hemolytic uremic 
      syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Interleukin-6 
      (IL-6) was elevated in the serum of 33 of 35 children with HUS (94%) and in 2 of 
      2 children with recurrent TTP. Serum IL-6 was higher in children with HUS who 
      developed anuria, extrarenal manifestations during the acute phase of illness 
      and/or chronic renal sequelae. Tumor necrosis factor-alpha (TNF-alpha) was 
      detected in the serum of 7 patients with HUS (20%) and 1 patient with TTP. IL-6 
      and TNF-alpha were elevated in the urine of 4 of 4 children with HUS and 2 of 2 
      children with TTP. Urinary levels were higher than serum levels, suggesting local 
      production of cytokines in the urinary tract. Sequential serum and urine samples 
      showed that IL-6 levels varied with disease activity. IL-6 and TNF-alpha were not 
      detected in the serum (n = 25) and urine (n = 15) of healthy children. We 
      conclude that IL-6 in urine may be used to monitor disease activity in HUS and 
      TTP.
FAU - Karpman, D
AU  - Karpman D
AD  - Department of Pediatrics, Lund University, Sweden.
FAU - Andreasson, A
AU  - Andreasson A
FAU - Thysell, H
AU  - Thysell H
FAU - Kaplan, B S
AU  - Kaplan BS
FAU - Svanborg, C
AU  - Svanborg C
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Globulins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood/urine
MH  - Female
MH  - Hemolytic-Uremic Syndrome/*immunology/therapy
MH  - Humans
MH  - Infant
MH  - Interleukin-6/blood/urine
MH  - Male
MH  - Purpura, Thrombotic Thrombocytopenic/*immunology/therapy
MH  - Renal Dialysis
MH  - Serum Globulins/urine
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1007/BF00868714 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 1995 Dec;9(6):694-9. doi: 10.1007/BF00868714.