PMID- 8748841
OWN - NLM
STAT- MEDLINE
DCOM- 19960930
LR  - 20190814
IS  - 0001-6268 (Print)
IS  - 0001-6268 (Linking)
VI  - 136
IP  - 3-4
DP  - 1995
TI  - Invasive meningioma: a tumour with high proliferating and "recurrence" potential.
PG  - 127-31
AB  - A study was undertaken to investigate the correlation between histological 
      invasiveness and proliferating potential and clinical recurrence in meningioma. 
      In 39 meningiomas, the histological findings at the tumour-brain interface zone 
      were classified into 3 types, consisting of 29 cases of non-invasion (NON). 7 
      cases of nodular invasion (NOD), and 3 cases of intermingled invasion (INT). 
      Proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer 
      region (AgNOR) indices were studied. PCNA indices (mean +/- standard error) of 
      NON, NOD. and INT were 1.7 +/- 0.1%, 5.2 +/- 0.5%, and 7.5 +/- 0.7%. 
      respectively, and the AgNOR indices (dot number/nucleus) were 1.50 +/- 0.03, 2.00 
      +/- 0.04, and 2.22 +/- 0.07, respectively. Significant differences were found 
      among the three types in both parameters. Clinically, tumour recurrence was 
      observed in 1/29 NON, 4/7 NOD, and 2/2 INT cases, indicating a higher incidence 
      of recurrence in invasive meningiomas (NOD plus INT). Four of 32 patients who 
      underwent gross total removal of the tumours showed recurrence, and all of these 
      four tumours were invasive meningiomas. The results of the present study showed 
      that tumour invasiveness as measured by PCNA + AgNOR indices correlated well with 
      high proliferative potential and clinical recurrence.
FAU - Suwa, T
AU  - Suwa T
AD  - Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, 
      Kanagawa, Japan.
FAU - Kawano, N
AU  - Kawano N
FAU - Oka, H
AU  - Oka H
FAU - Ito, H
AU  - Ito H
FAU - Kameya, T
AU  - Kameya T
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Brain/pathology
MH  - Cell Division/*physiology
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Meningeal Neoplasms/*pathology/surgery
MH  - Meninges/pathology
MH  - Meningioma/*pathology/surgery
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local/*pathology/surgery
MH  - Nucleolus Organizer Region/pathology
MH  - Proliferating Cell Nuclear Antigen/analysis
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF01410613 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 1995;136(3-4):127-31. doi: 10.1007/BF01410613.