PMID- 8749031
OWN - NLM
STAT- MEDLINE
DCOM- 19961024
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 287
IP  - 2
DP  - 1995 Dec 12
TI  - Pretreatment with beta-endorphin facilitates the attenuation of delta-opioid 
      receptor-mediated antinociception caused by delta-opioid receptor antisense 
      oligodeoxynucleotide.
PG  - 169-72
AB  - Intracerebroventricular (i.c.v.) pretreatment of male ICR mice with 
      beta-endorphin (0.6 nmol) or intrathecal (i.t.) pretreatment with antisense 
      oligodeoxynucleotide to delta-opioid receptor mRNA (163 pmol) alone given 24 h 
      earlier did not have any effect on i.t. administered delta-opioid receptor 
      agonist [D-Ala2]deltorphin II (6.4 nmol)-induced antinociception. However, a 
      concomitant i.c.v. pretreatments with beta-endorphin (0.08-0.6 nmol) and i.t. 
      pretreatment with delta-opioid receptor antisense oligodeoxynucleotide (163 pmol) 
      for 24 h dose-dependently attenuated i.t. challenged [D-Ala2]deltorphin 
      II-induced antinociception. A concomitant i.c.v. pretreatment with mu-opioid 
      receptor agonist [D-Ala2,N MePhe4,Gly(ol)5]enkephalin (DAMGO) or kappa-opioid 
      receptor agonist U50,488H and i.t. pretreatment with delta-opioid receptor 
      antisense oligodeoxynucleotide for 24 h did not affect i.t. challenged 
      [D-Ala2]deltorphin II-induced antinociception. beta-Endorphin given supraspinally 
      has been documented to release [Met5]enkephalin acting on delta-opioid receptors 
      in the spinal cord. Our results indicate that supraspinal pretreatment with 
      beta-endorphin selectively causes a loss of spinal delta-opioid receptor-mediated 
      antinociception in mice receiving delta-opioid receptor antisense 
      oligodeoxynucleotide.
FAU - Tseng, L F
AU  - Tseng LF
AD  - Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, 
      USA.
FAU - Narita, M
AU  - Narita M
FAU - Kampine, J P
AU  - Kampine JP
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Receptors, Opioid, delta)
RN  - 60617-12-1 (beta-Endorphin)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Injections, Spinal
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Molecular Sequence Data
MH  - Nociceptors/*drug effects
MH  - Oligonucleotides, Antisense/*pharmacology
MH  - Pain Measurement
MH  - Receptors, Opioid, delta/*drug effects
MH  - beta-Endorphin/*pharmacology
EDAT- 1995/12/12 00:00
MHDA- 1995/12/12 00:01
CRDT- 1995/12/12 00:00
PHST- 1995/12/12 00:00 [pubmed]
PHST- 1995/12/12 00:01 [medline]
PHST- 1995/12/12 00:00 [entrez]
AID - 0014-2999(95)00587-0 [pii]
AID - 10.1016/0014-2999(95)00587-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1995 Dec 12;287(2):169-72. doi: 10.1016/0014-2999(95)00587-0.