PMID- 8750290
OWN - NLM
STAT- MEDLINE
DCOM- 19960919
LR  - 20190905
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 15
IP  - 12
DP  - 1995 Dec
TI  - Prenatal identification of i(Yp) by molecular cytogenetic analysis.
PG  - 1115-9
AB  - An i(Yp) is a rare marker chromosome. We present a case of de novo 46,X,i(Yp) 
      detected prenatally in an amniotic fluid specimen. Fluorescence in situ 
      hybridization (FISH) studies using a panel of Y-specific biotinylated DNA probes 
      identified the marker chromosome as i(Yp). Comparative genomic hybridization 
      (CGH) studies further confirmed the diagnosis. Upon pregnancy termination, 
      external examination of the fetus revealed a generally well-developed male fetus 
      with slight facial dysmorphism and prominent rocker-bottom feet. The molecular 
      cytogenetic data in this case proved very useful in genetic counselling and 
      served as a good example illustrating the important role of molecular techniques 
      for accurate identification of marker chromosomes.
FAU - Wang, B B
AU  - Wang BB
AD  - Prenatal Diagnostic Center of Southern California, Inc., Beverly Hills 90211, 
      USA.
FAU - Yu, L C
AU  - Yu LC
FAU - Peng, W
AU  - Peng W
FAU - Falk, R E
AU  - Falk RE
FAU - Williams, J 3rd
AU  - Williams J 3rd
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Amniotic Fluid
MH  - Chromosome Fragility
MH  - Congenital Abnormalities/genetics
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Karyotyping
MH  - Male
MH  - Oocyte Donation
MH  - *Prenatal Diagnosis
MH  - Sex Chromosome Aberrations/*diagnosis
MH  - Surrogate Mothers
MH  - *Y Chromosome
EDAT- 1995/12/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1002/pd.1970151206 [doi]
PST - ppublish
SO  - Prenat Diagn. 1995 Dec;15(12):1115-9. doi: 10.1002/pd.1970151206.