PMID- 8751386
OWN - NLM
STAT- MEDLINE
DCOM- 19960925
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 73
IP  - 4
DP  - 1996
TI  - Coding sequence and chromosome mapping of the human gene (CDC46) for replication 
      protein hCdc46/Mcm5.
PG  - 317-21
AB  - We have isolated the complete cDNA sequence encoding the human homolog of the 
      yeast replication protein Cdc46/Mcm5. The cDNA was used as a probe for 
      chromosomal fluorescence in situ hybridization (FISH), which localized the human 
      Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2. This is the fourth human 
      Mcm gene whose chromosome region has been determined, and it is now apparent that 
      human Mcm genes are widely distributed in the genome. As deduced from the cDNA 
      sequence, human protein hCdc46 is composed of 734 amino acids and contains a 
      central region that is almost 80% identical with the yeast protein. 
      Immunoprecipitation experiments with hCdc46-specific antibodies confirm that 
      essentially all nuclear hCdc46 proteins form a stable dimeric complex with 
      protein P1Mcm3.
FAU - Paul, R
AU  - Paul R
AD  - Division of Biology, Universitat Konstanz, Germany.
FAU - Hu, B
AU  - Hu B
FAU - Musahl, C
AU  - Musahl C
FAU - Hameister, H
AU  - Hameister H
FAU - Knippers, R
AU  - Knippers R
LA  - eng
SI  - GENBANK/X74795
SI  - SWISSPROT/P33992
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (MCM5 protein, S cerevisiae)
RN  - 0 (MCM5 protein, human)
RN  - 0 (Saccharomyces cerevisiae Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Cell Cycle Proteins/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Saccharomyces cerevisiae/genetics
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000134366 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1996;73(4):317-21. doi: 10.1159/000134366.