PMID- 8751390
OWN - NLM
STAT- MEDLINE
DCOM- 19960925
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 73
IP  - 4
DP  - 1996
TI  - Identification and mapping of type 1 neurofibromatosis (NF1) homologous loci.
PG  - 334-40
AB  - During the establishment of a YAC contig for the type 1 neurofibromatosis (NF1) 
      region on human chromosome 17q11.2, several YAC clones were isolated which 
      originated from a different chromosome but which retained strong homology to NF1 
      coding regions (Marchuk et al., 1992). Fluorescence in situ hybridization (FISH) 
      using these clones has identified NF1-homologous loci on several human 
      chromosomes, including 2, 14, 15, 21, and 22. PCR amplification using primers 
      originally designed to amplify NF1 exons has confirmed these chromosome 
      localizations and, in addition, has revealed NF1-homologous sequences on 
      chromosomes 12 and 20. Sequence analysis of the amplified products has 
      demonstrated that (1) most of these loci have > 90% identity with NF1 sequences; 
      (2) most of these loci represent nonprocessed pseudogenes; and (3) for the 
      chromosome 12 locus, the two described regions of homology with NF1 have open 
      reading frames. Finally, we have identified two novel alpha-satellite DNA repeat 
      units in proximity to NF1-homologous sequences on chromosome 14. Their 
      association suggests a mechanism for dispersion of the NF1-homologous loci based 
      on alpha-satellite-mediated exchange between nonhomologous chromosomes.
FAU - Cummings, L M
AU  - Cummings LM
AD  - Laboratory of Cancer Genetics, National Center for Human Genome Research 
      Bethesda, MD, USA.
FAU - Trent, J M
AU  - Trent JM
FAU - Marchuk, D A
AU  - Marchuk DA
LA  - eng
SI  - GENBANK/U31754
SI  - GENBANK/U31755
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA, Recombinant)
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Base Sequence
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human/*genetics
MH  - DNA, Recombinant/genetics
MH  - DNA, Satellite/genetics
MH  - *Genes, Neurofibromatosis 1
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Pseudogenes
MH  - Sequence Alignment
MH  - *Sequence Homology, Nucleic Acid
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000134370 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1996;73(4):334-40. doi: 10.1159/000134370.