PMID- 8752627
OWN - NLM
STAT- MEDLINE
DCOM- 19961127
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 66
IP  - 1
DP  - 1996 Jul
TI  - Use of recombinant human follicle-stimulating hormone for in vitro 
      fertilization-embryo transfer after severe systemic immunoglobulin E-mediated 
      reaction to urofollitropin.
PG  - 148-50
AB  - OBJECTIVE: To report the successful use of recombinant human FSH in a patient 
      with a history of a severe systemic immunoglobulin E (IgE)-mediated reaction to 
      urofollitropin. SETTING: University hospital. PATIENT: A 38-year-old infertility 
      patient who had experienced a whole-body rash with hives, tachycardia, fever, and 
      other symptoms after urofollitropin administration, with confirmation of 
      IgE-mediated sensitivity to urofollitropin by intradermal skin testing. 
      INTERVENTION: In vitro fertilization-ET after the use of recombinant human FSH to 
      stimulate ovarian follicular development. RESULTS: Establishment of a clinical 
      pregnancy. CONCLUSIONS: Our case provides evidence for the involvement of 
      nongonadotropin proteins as the direct cause of some adverse reactions from 
      conventional urine-derived human FSH preparations.
FAU - Phipps, W R
AU  - Phipps WR
AD  - Department of Obstetrics-Gynecology, University of Rochester, New York 14642, 
      USA.
FAU - Holden, D
AU  - Holden D
FAU - Sheehan, R K
AU  - Sheehan RK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Recombinant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adult
MH  - Drug Hypersensitivity/*immunology
MH  - *Embryo Transfer
MH  - Female
MH  - *Fertilization in Vitro
MH  - Follicle Stimulating Hormone/*immunology/*therapeutic use/urine
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Pregnancy
MH  - Recombinant Proteins
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - S0015-0282(16)58403-9 [pii]
AID - 10.1016/s0015-0282(16)58403-9 [doi]
PST - ppublish
SO  - Fertil Steril. 1996 Jul;66(1):148-50. doi: 10.1016/s0015-0282(16)58403-9.