PMID- 8755632
OWN - NLM
STAT- MEDLINE
DCOM- 19960923
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 98
IP  - 2
DP  - 1996 Jul 15
TI  - Association and cosegregation of stroke with impaired endothelium-dependent 
      vasorelaxation in stroke prone, spontaneously hypertensive rats.
PG  - 256-61
AB  - While hypertension is a major risk factor for stroke, it is not its sole 
      determinant. Despite similar blood pressures, spontaneously hypertensive rats 
      (SHR) do not share the predisposition to cerebrovascular disease typical of 
      stroke-prone spontaneously hypertensive rats (SHRSP). We investigated vascular 
      function in male SHR and SHRSP as well as in SHRSP/SHR-F2 hybrid animals. Animals 
      were maintained on the appropriate dietary regimen necessary for the 
      manifestation of stroke. Among the hybrid animals, a group of stroke-prone and a 
      group of stroke-resistant rats were selected. Blood pressure was similar in all 
      groups. Endothelium-independent vascular reactivity tested on isolated rings of 
      thoracic aorta and basilar artery after death showed similar contractile and 
      dilatory responses to serotonin and nitroglycerin, respectively, in all groups. 
      In contrast, endothelium-dependent relaxation, in response to acetylcholine or 
      substance P, was markedly reduced in SHRSP compared with SHR. Similarly, reduced 
      vasodilatory responses were present in aortae of F2 rats that had suffered a 
      stroke when compared with SHR or F2 rats resistant to stroke. The observed 
      association and cosegregation of stroke with significant and specific impairment 
      of endothelium-dependent vasorelaxation among SHRSP and stroke-prone F2 hybrids, 
      respectively, suggest a potential causal role of altered endothelium-dependent 
      vascular relaxation in the pathogenesis of stroke.
FAU - Volpe, M
AU  - Volpe M
AD  - Department of Experimental Medicine and Pathology, "La Sapienza" University, 
      Rome, Italy.
FAU - Iaccarino, G
AU  - Iaccarino G
FAU - Vecchione, C
AU  - Vecchione C
FAU - Rizzoni, D
AU  - Rizzoni D
FAU - Russo, R
AU  - Russo R
FAU - Rubattu, S
AU  - Rubattu S
FAU - Condorelli, G
AU  - Condorelli G
FAU - Ganten, U
AU  - Ganten U
FAU - Ganten, D
AU  - Ganten D
FAU - Trimarco, B
AU  - Trimarco B
FAU - Lindpaintner, K
AU  - Lindpaintner K
LA  - eng
GR  - K04-HL03138-01/HL/NHLBI NIH HHS/United States
GR  - R01-HL5641101/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 169D1260KM (Nitroprusside)
RN  - 333DO1RDJY (Serotonin)
RN  - 33507-63-0 (Substance P)
RN  - G59M7S0WS3 (Nitroglycerin)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Animals
MH  - Aorta, Thoracic/pathology/physiology/*physiopathology
MH  - Basilar Artery/physiology/*physiopathology
MH  - Blood Pressure
MH  - Cerebrovascular Disorders/genetics/pathology/*physiopathology
MH  - Crosses, Genetic
MH  - Disease Susceptibility
MH  - Endothelium, Vascular/physiology/*physiopathology
MH  - Female
MH  - Heart Rate
MH  - Hypertension/genetics/pathology/*physiopathology
MH  - In Vitro Techniques
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth, Vascular/pathology/physiology/*physiopathology
MH  - Nitroglycerin/pharmacology
MH  - Nitroprusside/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Serotonin/pharmacology
MH  - Substance P/pharmacology
MH  - *Vasodilation/drug effects
PMC - PMC507425
EDAT- 1996/07/15 00:00
MHDA- 1996/07/15 00:01
PMCR- 1996/07/15
CRDT- 1996/07/15 00:00
PHST- 1996/07/15 00:00 [pubmed]
PHST- 1996/07/15 00:01 [medline]
PHST- 1996/07/15 00:00 [entrez]
PHST- 1996/07/15 00:00 [pmc-release]
AID - 10.1172/JCI118787 [doi]
PST - ppublish
SO  - J Clin Invest. 1996 Jul 15;98(2):256-61. doi: 10.1172/JCI118787.