PMID- 8756345
OWN - NLM
STAT- MEDLINE
DCOM- 19960924
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 10
IP  - 15
DP  - 1996 Aug 1
TI  - Early loss of the retinoblastoma gene is associated with impaired growth 
      inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
PG  - 1870-9
AB  - To better understand the cell lineage-specific character of retinoblastoma (Rb) 
      gene inactivation during tumor formation, the earliest stages of spontaneous 
      melanotroph carcinogenesis in Rb+/- heterozygous mice have been subjected to 
      sequential analyses. The first atypical cells are detected in the pituitary 
      intermediate lobe during a period corresponding to the cessation of melanotroph 
      proliferation between 35 and 60 days after birth. Atypical cells contain no 
      wild-type copy of the Rb gene and synchronously form early atypical proliferates 
      (EAP) in the subsequent 30-60 day period. In contrast to surrounding mature 
      melanotrophs with the wild-type Rb gene, Rb-negative cells in EAP continue to 
      proliferate well past postnatal day 60, and fail to be innervated by growth 
      inhibitory dopaminergic nerve terminals. Atypical melanotrophs remain competent 
      for dopamine D2 receptor stimulation and undergo S-phase apoptosis in close 
      proximity to nerve terminals. These results indicate a key role for the Rb 
      protein in the onset of neuron-neuroendocrine cell interactions. This role may 
      explain cell-type-specific neuroendocrine carcinogenesis associated with 
      inactivation of the ubiquitously expressed Rb gene.
FAU - Nikitin AYu
AU  - Nikitin AYu
AD  - Center for Molecular Medicine/Institute of Biotechnology, University of Texas 
      Health Science Center at San Antonio 78245, USA.
FAU - Lee, W H
AU  - Lee WH
LA  - eng
GR  - CA 58318/CA/NCI NIH HHS/United States
GR  - EY 05758/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Dopamine Agonists)
RN  - 0 (Receptors, Dopamine)
RN  - 3A64E3G5ZO (Bromocriptine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Base Sequence
MH  - Bromocriptine/pharmacology
MH  - Cell Division
MH  - Cell Transformation, Neoplastic/genetics
MH  - Dopamine/metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Gene Deletion
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, Retinoblastoma/*genetics
MH  - Heterozygote
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Molecular Sequence Data
MH  - Pituitary Gland/growth & development/*innervation/*pathology
MH  - Pituitary Neoplasms/chemically induced/*genetics/pathology
MH  - Receptors, Dopamine/metabolism
MH  - Tumor Cells, Cultured/drug effects
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1101/gad.10.15.1870 [doi]
PST - ppublish
SO  - Genes Dev. 1996 Aug 1;10(15):1870-9. doi: 10.1101/gad.10.15.1870.