PMID- 8757971
OWN - NLM
STAT- MEDLINE
DCOM- 19960925
LR  - 20191024
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 64
IP  - 1
DP  - 1996 Jul
TI  - Philadelphia chromosome-negative cells with trisomy 8 after busulfan and 
      interferon treatment of Ph1-positive chronic myelogenous leukemia.
PG  - 73-7
AB  - A 48-year-old Japanese man with Philadelphia chromosome (Ph1)-positive chronic 
      myelogenous leukemia (CML) was treated with busulfan followed by interferon-alpha 
      (IFN-alpha). Ten months after IFN-alpha treatment, Ph1(-) cells with trisomy 8 
      were detected by the conventional banding technique and fluorescence in situ 
      hybridization (FISH) analysis. Add(Y)(q12) was also found in Ph1(-) cells with 
      trisomy 8. Although Ph1(+) cells disappeared after the treatment with IFN-alpha, 
      Ph1(-) cells with trisomy 8 did not. We summarize four previous case reports of 
      Ph1(+) CML developing Ph1(-) cells with trisomy 8. All four patients had received 
      busulfan and IFN-alpha. These drugs may be related to the ontogenesis of Ph1(-) 
      cells with trisomy 8, but the significance of Ph1(-) cells with trisomy 8 is not 
      known, and further observation is needed.
FAU - Izumi, T
AU  - Izumi T
AD  - Department of Medicine, Jichi Medical School, Tochigi-ken, Japan.
FAU - Imagawa, S
AU  - Imagawa S
FAU - Hatake, K
AU  - Hatake K
FAU - Miura, Y
AU  - Miura Y
FAU - Ariyama, T
AU  - Ariyama T
FAU - Inazawa, J
AU  - Inazawa J
FAU - Abe, T
AU  - Abe T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 0 (Interferon-alpha)
RN  - G1LN9045DK (Busulfan)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Antineoplastic Agents, Alkylating/*adverse effects
MH  - Busulfan/*adverse effects
MH  - *Chromosomes, Human, Pair 8
MH  - Combined Modality Therapy
MH  - Humans
MH  - Interferon-alpha/*adverse effects
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/*therapy
MH  - Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
RF  - 17
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 0925571096004690 [pii]
AID - 10.1016/0925-5710(96)00469-0 [doi]
PST - ppublish
SO  - Int J Hematol. 1996 Jul;64(1):73-7. doi: 10.1016/0925-5710(96)00469-0.