PMID- 8758273
OWN - NLM
STAT- MEDLINE
DCOM- 19960920
LR  - 20061115
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 76
IP  - 4
DP  - 1996 Apr
TI  - [C-myc activation by translocation in human primary non-small cell lung cancer].
PG  - 275-7
AB  - OBJECTIVE: Lung cancer is one of the most common human neoplasms. The 
      carcinogenesis and development of lung cancer are related to activation and 
      inactivation of many oncogenes and tumor-suppressor genes. We reported c-myc 
      activation by translocation in SV40T-transformed human bronchial epithelial cells 
      and lung cancer cell line before. In order to confirm that c-myc translocation 
      exists in human primary non-small cell lung cancer, we continued our studies in 
      12 primary human lung cancers. METHODS: We applied major fluorescence in situ 
      hybridization (FISH) in combination with immunohistochemistry. RESULTS: c-myc 
      translocation was detected in two cases of the 12 primary lung cancers. 
      Overexpression of c-myc was detected in the two cases by means of 
      immunohistochemistry. CONCLUSION: These results suggest that c-myc can be 
      activated by translocation in human primary lung cancer.
FAU - Lu, Y
AU  - Lu Y
AD  - Cancer Institute, CAMS & PUMC, Beijing.
FAU - Cheng, S
AU  - Cheng S
FAU - Guo, S
AU  - Guo S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adenocarcinoma/genetics
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*genetics
MH  - Carcinoma, Squamous Cell/genetics
MH  - Gene Expression Regulation
MH  - Genes, myc/*genetics
MH  - Humans
MH  - Lung Neoplasms/*genetics
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-myc/biosynthesis
MH  - *Translocation, Genetic
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 1996 Apr;76(4):275-7.