PMID- 8760789
OWN - NLM
STAT- MEDLINE
DCOM- 19960923
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 184
IP  - 2
DP  - 1996 Aug 1
TI  - Histamine selectively enhances human immunoglobulin E (IgE) and IgG4 production 
      induced by anti-CD58 monoclonal antibody.
PG  - 357-64
AB  - We studied the effects of histamine on human immunoglobulin (IgE) and IgG4 
      production. Histamine selectively enhanced IgE and IgG4 production in purified 
      surface IgE and IgG4 negative (sIgE-sIgG4-) B cells from normal donors stimulated 
      with interleukin (IL)-4 plus anti-CD58 or IL-13 plus anti-CD58 monoclonal 
      antibody (mAb) without affecting production of IgG1, IgG2, IgG3, IgM, IgA1, or 
      IgA2. In cultures with IL-4 plus anti-CD58 mAb, histamine-induced enhancement of 
      IgE and IgG4 production was specifically blocked by thioperamide (H3 receptor 
      antagonist), and was inhibited by anti-IL-10 antibody (Ab). In contrast, in 
      cultures with IL-13 plus anti-CD58 mAb, histamine-induced enhancement was blocked 
      by dimaprit (H1 receptor antagonist), and was inhibited by anti-IL-6 mAb. 
      Histamine also enhanced IgE and IgG4 production by in vivo-generated sIgE+ and 
      sIgG4+ B cells, respectively, from atopic patients; enhancement was blocked by 
      dimaprit and thioperamide, and was inhibited by anti-IL-6 mAb and anti-IL-10 Ab. 
      In sIgE-sIgG4- B cells, IL-4 plus anti-CD58 mAb induced IL-10 production and 
      IL-10 receptor expression, whereas IL-13 plus anti-CD58 mAb induced IL-6 
      production and IL-6 receptor expression. Histamine increased IL-10 and IL-6 
      production without affecting IL-10 and IL-6 receptor expression, in cultures with 
      IL-4 plus anti-CD58 mAb and with IL-13 plus anti-CD58 mAb, respectively, which 
      was blocked by thioperamide and dimaprit, respectively. In contrast, sIgE+ and 
      sIgG4+ B cells spontaneously produced both IL-6 and IL-10 and constitutively 
      expressed IL-6 and IL-10 receptors, and histamine increased IL-6 and IL-10 
      production without affecting IL-6 or IL-10 receptor expression, which was blocked 
      by thioperamide and dimaprit. These results indicate that histamine enhanced IgE 
      and IgG4 production by increasing endogenous IL-6 and IL-10 production via H1 and 
      H3 receptors, respectively.
FAU - Kimata, H
AU  - Kimata H
AD  - Department of Pediatrics, Unitika Central Hospital, Kyoto, Japan.
FAU - Fujimoto, M
AU  - Fujimoto M
FAU - Ishioka, C
AU  - Ishioka C
FAU - Yoshida, A
AU  - Yoshida A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD58 Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Histamine H1)
RN  - 0 (Receptors, Histamine H2)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - B-Lymphocyte Subsets/*metabolism
MH  - CD58 Antigens/*physiology
MH  - Cells, Cultured
MH  - Histamine/*administration & dosage
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/*biosynthesis
MH  - Interleukin-10/metabolism
MH  - Interleukin-13/administration & dosage
MH  - Interleukin-6/metabolism
MH  - Palatine Tonsil/cytology
MH  - Receptors, Histamine H1/metabolism
MH  - Receptors, Histamine H2/metabolism
PMC - PMC2192716
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
PMCR- 1997/02/01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PHST- 1997/02/01 00:00 [pmc-release]
AID - 96343846 [pii]
AID - 10.1084/jem.184.2.357 [doi]
PST - ppublish
SO  - J Exp Med. 1996 Aug 1;184(2):357-64. doi: 10.1084/jem.184.2.357.