PMID- 8762527
OWN - NLM
STAT- MEDLINE
DCOM- 19961210
LR  - 20061115
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 30
IP  - 6
DP  - 1995
TI  - [Expression of P53 protein in laryngeal carcinoma and its clinical significance].
PG  - 354-6
AB  - Using the monoclonal antibody DO-7, the expressions of P53 protein in 38 cases of 
      laryngeal squamous cell carcinoma (LSCC), and 29 cases of laryngeal benign 
      neoplasms (LBN) were studied immunohistochemically. The results showed that: (1) 
      25 of 38 (66%) LSCCs, but only 2 of 29 (7%) LBNs showed expression of mutant-type 
      P53 protein. The high rate of P53 protein expression was related to the 
      occurrence of laryngeal carcinoma, and is valuable in diagnosis and differential 
      diagnosis of laryngeal carcinoma; (2) in some LSCCs, the mutant-type P53 protein 
      was also expressed in dysplastic epithelium near the cancer tissues. These 
      epithelial cells near the tumor in which P53 gene has been altered, probably are 
      the source or portent of tumor recurrence; (3) the five year survival rate of 
      mutant-type P53 protein negative LSCC patients was higher than that of positive 
      LSCC patients. The expression of mutant-type P53 protein might be related to LSCC 
      prognosis.
FAU - Wang, D
AU  - Wang D
AD  - First Affiliated Hospital, FuJian Medical College, Fuzhou.
FAU - Yi, Z
AU  - Yi Z
FAU - Yang, F
AU  - Yang F
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Female
MH  - Gene Expression
MH  - Genes, p53
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Papilloma/genetics/metabolism
MH  - Precancerous Conditions/genetics/metabolism
MH  - Prognosis
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 1995;30(6):354-6.