PMID- 8765632
OWN - NLM
STAT- MEDLINE
DCOM- 19960925
LR  - 20190630
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 129
IP  - 2
DP  - 1996 Aug
TI  - Human herpesvirus 7 infection associated with central nervous system 
      manifestations.
PG  - 301-5
AB  - The clinical features of infection with human herpesvirus 7 (HHV-7) are not well 
      described. Exanthem subitum is the only illness that is confirmed to be caused by 
      HHV-7. We report two children who had exanthem subitum associated with central 
      nervous system manifestations. Two strains of HHV-7 were isolated sequentially 
      from peripheral blood mononuclear cells and saliva of the some child who had 
      exanthem subitum complicated with acute hemiplegia in childhood. Two strains were 
      confirmed to be HHV-7 by means of monoclonal antibodies to human herpesvirus 6 
      (HHV-6) and HHV-7, polymerase chain reaction, and DNA analysis. During the 
      convalescent period, the antibody titer to HHV-7 rose from less than 1:10 to 
      1:320, whereas the antibody titer to HHV-6 remained less than 1:10. Another child 
      with exanthem subitum complicated by acute hemiplegia had serologic evidence of 
      primary HHV-7 infection. These two cases demonstrate a new relationship between 
      HHV-7 and central nervous system symptoms.
FAU - Torigoe, S
AU  - Torigoe S
AD  - Department of Pediatrics, Shingu Municipal Hospital, Wakayama, Japan.
FAU - Koide, W
AU  - Koide W
FAU - Yamada, M
AU  - Yamada M
FAU - Miyashiro, E
AU  - Miyashiro E
FAU - Tanaka-Taya, K
AU  - Tanaka-Taya K
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antibodies, Viral/analysis
MH  - Brain Diseases/pathology/*virology
MH  - DNA, Viral/analysis
MH  - Epilepsy, Generalized/virology
MH  - Epilepsy, Tonic-Clonic/virology
MH  - Exanthema Subitum/pathology/virology
MH  - Female
MH  - Hemiplegia/virology
MH  - Herpesviridae Infections/*pathology
MH  - Herpesvirus 6, Human/genetics/immunology/isolation & purification
MH  - *Herpesvirus 7, Human/genetics/immunology/isolation & purification
MH  - Humans
MH  - Infant
MH  - Leukocytes, Mononuclear/virology
MH  - Polymerase Chain Reaction
MH  - Saliva/virology
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - S0022-3476(96)70259-7 [pii]
AID - 10.1016/s0022-3476(96)70259-7 [doi]
PST - ppublish
SO  - J Pediatr. 1996 Aug;129(2):301-5. doi: 10.1016/s0022-3476(96)70259-7.