PMID- 8765978
OWN - NLM
STAT- MEDLINE
DCOM- 19961217
LR  - 20190905
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 135
IP  - 1
DP  - 1996 Jul
TI  - High-affinity growth hormone binding protein, insulin-like growth factor I and 
      insulin-like growth factor binding protein 3 in adults with growth hormone 
      deficiency.
PG  - 82-6
AB  - The high-affinity growth hormone binding protein (GHBP) circulates in human blood 
      and represents the extracellular domain of the growth hormone (GH) receptor. The 
      effects of GH deficiency on GHBP in adults are not clear. The aim of this study 
      was to evaluate serum GHBP levels in adults with GH deficiency and to assess 
      whether GHBP measurement may contribute to the diagnosis of adult GH deficiency, 
      based on a two-step model. We measured insulin-like growth factor I (IGF-I), IGF 
      binding protein 3 (IGFBP-3) and GHBP levels in serum samples of 36 patients with 
      adult-onset GH deficiency. The GHBP levels were measured by FPLC size-exclusion 
      chromatography; IGF-I and IGFBP-3 levels were measured by RIA. Serum GHBP levels 
      were elevated above the upper limit of the 95% confidence interval in 26 
      patients, whereas IGF-I and IGFBP-3 levels were low in 10 patients and in 16 
      patients, respectively. The combination of low serum IGF-I and low IGFBP-3 levels 
      was found in 10 patients. In nine patients, serum IGF-I levels were low, with 
      elevated GHBP levels. Low serum IGF-I, low IGFBP-3 and elevated GHBP levels were 
      found in five patients. Only four out of 36 patients had serum IGF-I, IGFBP-3 and 
      GHBP levels that were within the 95% confidence interval of the control values. 
      We conclude that adults with acquired GH deficiency have elevated GHBP levels in 
      comparison to healthy subjects. We suggest that measurement of GHBP levels might 
      contribute to the diagnosis of adult GH deficiency, though further research is 
      required to study the additional value of GHBP measurements.
FAU - Roelen, C A
AU  - Roelen CA
AD  - Department of Endocrinology, University Hospital Utrecht, The Netherlands.
FAU - Koppeschaar, H P
AU  - Koppeschaar HP
FAU - de Vries, W R
AU  - de Vries WR
FAU - Zelissen, P M
AU  - Zelissen PM
FAU - Snel, Y E
AU  - Snel YE
FAU - Doerga, M E
AU  - Doerga ME
FAU - Thijssen, J H
AU  - Thijssen JH
FAU - Blankenstein, R A
AU  - Blankenstein RA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - W06KFL3RDT (somatotropin-binding protein)
SB  - IM
MH  - Adult
MH  - Binding, Competitive
MH  - Carrier Proteins/*blood
MH  - Female
MH  - Growth Hormone/*deficiency
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Osmolar Concentration
MH  - Postmenopause/blood
MH  - Premenopause/blood
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1530/eje.0.1350082 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1996 Jul;135(1):82-6. doi: 10.1530/eje.0.1350082.