PMID- 8766134
OWN - NLM
STAT- MEDLINE
DCOM- 19961107
LR  - 20041117
IS  - 0003-3995 (Print)
IS  - 0003-3995 (Linking)
VI  - 39
IP  - 2
DP  - 1996
TI  - Genetic counselling in a prenatal marker chromosome identified as an i (18p) by 
      in situ hybridization.
PG  - 61-3
AB  - The origin of a de novo metacentric small marker chromosome found in a 
      cytogenetic study in amniotic fluid was determined by fluorescence in situ 
      hybridization (FISH) using chromosome specific probes. It was identified as an 
      isochromosome 18p. We want to emphasize that when an extra chromosome is found in 
      prenatal diagnosis and it cannot be identified by conventional cytogenetics 
      banding, FISH should be applied in order to give real risks for fetal anomalies 
      and an accurate genetic counselling.
FAU - Darnaude, M T
AU  - Darnaude MT
AD  - Laboratory of Genetics, Mostoles Hospital, Madrid, Spain.
FAU - Diaz de Bustamante, A
AU  - Diaz de Bustamante A
FAU - Cabello, P
AU  - Cabello P
FAU - Vallcorba, I
AU  - Vallcorba I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Genet
JT  - Annales de genetique
JID - 0370562
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Amniotic Fluid/physiology
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 18
MH  - Fibroblasts/physiology
MH  - *Genetic Counseling
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Karyotyping
MH  - Lymphocytes/physiology
MH  - Male
MH  - Prenatal Diagnosis/*methods
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Genet. 1996;39(2):61-3.