PMID- 8768798
OWN - NLM
STAT- MEDLINE
DCOM- 19960925
LR  - 20180216
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 110
IP  - 4
DP  - 1996 Aug
TI  - Dual effect of ammonium persulfate on the generation of leukotrienes from human 
      neutrophil granulocytes.
PG  - 318-24
AB  - Occupationally induced hypersensitive reactions towards chemical compounds are 
      increasingly observed. In this regard ammonium persulfate (APS) is reported as an 
      inducer of erythema, urticaria, eczema, rhinitis and bronchial asthma. On the 
      basis of these reactions, persulfates obviously show some characteristics of 
      skin-sensitizing as well as respiratory allergens. We measured the effect of APS 
      on the release of inflammatory mediators, i.e. leukotriene B4 (LTB4), from human 
      polymorphonuclear neutrophils (PMN). The effect of the persulfate was analyzed in 
      comparison of the corresponding sulfate. After different cellular activation 
      either with the Ca ionophore A23187, the tripeptide 
      formyl-methionyl-leucyl-phenylalanine (fMLP) or sodium fluoride (NaF) 
      coincubation of PMN with APS led to a diminished generation of LTB4. In addition 
      it was demonstrated that APS decreased the stability of leukotrienes in cell-free 
      systems. However, cells which were preactivated with APS and subsequently washed 
      showed an increase in leukotriene formation after stimulation with fMLP or NaF 
      but not with the Ca ionophore. Thus, the concentration of APS at local tissue 
      sites as well as the occurrence and nature of a secondary cell-activating 
      stimulus finally determine to what extent persulfates will interfere with 
      cellular functions, e.g. mediator suppression or induction, which are then 
      responsible for clinical disease processes.
FAU - Koller, M
AU  - Koller M
AD  - Medizinische Mikrobiologie und Immunologie, AG Infektabwehrmechanismen, 
      Ruhr-Universitat Bochum, Germany.
FAU - Hilger, R A
AU  - Hilger RA
FAU - Konig, W
AU  - Konig W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Leukotrienes)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 22QF6L357F (ammonium peroxydisulfate)
RN  - SU46BAM238 (Ammonium Sulfate)
SB  - IM
MH  - Ammonium Sulfate/*pharmacology
MH  - Cell-Free System/drug effects
MH  - Drug Stability
MH  - Humans
MH  - Leukotriene B4/biosynthesis
MH  - Leukotrienes/*biosynthesis
MH  - Neutrophils/*drug effects/*metabolism
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1159/000237323 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1996 Aug;110(4):318-24. doi: 10.1159/000237323.