PMID- 8770284
OWN - NLM
STAT- MEDLINE
DCOM- 19961022
LR  - 20200304
IS  - 0914-7187 (Print)
IS  - 0914-7187 (Linking)
VI  - 9
IP  - 4
DP  - 1995 Nov
TI  - Error analysis of autoradiography method for measurement of cerebral blood flow 
      by 123I-IMP brain SPECT: a comparison study with table look-up method and 
      microsphere model method.
PG  - 185-190
AB  - N-isopropyl-p-[123I]iodoamphetamine (IMP) has been commonly used as a cerebral 
      blood flow tracer, but, significant clearance of IMP from the brain to the blood 
      causes underestimation of cerebral blood flow (CBF) as compared with true CBF 
      when the conventional microsphere model method is applied. Previously, we 
      reported an "Autoradiography method" (ARG method) for measuring CBF by using IMP 
      in which this clearance effect was corrected. This method was based on a 
      two-compartment model (influx: K1, efflux: k2, K1/k2 = distribution volume of IMP 
      (Vd)), the K1 (corresponding to CBF) being obtained form the table which showed a 
      correlation between CBF and the brain counts of SPECT scan with a constant Vd 
      value. Arterial input data used were obtained by one point blood sampling 10 min 
      after IMP infusion against the standard input function. In the present study, the 
      ARG method was compared with the table look-up method (TLU method) and the 
      conventional microsphere model method (MS method) for 30 subjects. When the Vd 
      value in the ARG method was assumed to be 50 ml/ml, CBF values obtained by the 
      ARG method were correlated well with those obtained by the TLU method (Y = 
      1.04X-2.5; X: TLU, Y: ARG r = 0.97) and those obtained by the MS method (Y = 
      0.82X + 12.1; X: ARG, Y: MS, r = 0.84). But, when the Vd value was assumed to be 
      more or less than 50 ml/ml, ARG method CBF were under- or overestimated compared 
      with the TLU method. This indicated that the ARG method could be a reliable 
      method for CBF measurement if the Vd was determined properly. CBF values obtained 
      by the MS method were actually 13.2% higher than those obtained by the ARG method 
      against previous studies. As reasons for this, errors in the effects of 
      gray-white matter mixture in the ARG method and in estimation of the SPECT brain 
      counts at 8 min in the MS method were considered.
FAU - Ito, H
AU  - Ito H
AD  - Department of Nuclear Medicine and Radiology, Tohoku University, Sendai, Japan.
FAU - Ishii, K
AU  - Ishii K
FAU - Atsumi, H
AU  - Atsumi H
FAU - Inukai, Y
AU  - Inukai Y
FAU - Abe, S
AU  - Abe S
FAU - Sato, M
AU  - Sato M
FAU - Kinoshita, T
AU  - Kinoshita T
FAU - Kawashima, R
AU  - Kawashima R
FAU - Ono, S
AU  - Ono S
FAU - Fukuda, H
AU  - Fukuda H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Amphetamines)
RN  - 0 (Iodine Radioisotopes)
RN  - C2A5X08042 (Iofetamine)
SB  - IM
MH  - *Amphetamines
MH  - Autoradiography/*methods/statistics & numerical data
MH  - *Cerebrovascular Circulation
MH  - Evaluation Studies as Topic
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Iofetamine
MH  - Microspheres
MH  - Tomography, Emission-Computed, Single-Photon/*methods/statistics & numerical data
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
AID - 10.1007/BF03168399 [doi]
PST - ppublish
SO  - Ann Nucl Med. 1995 Nov;9(4):185-190. doi: 10.1007/BF03168399.