PMID- 8770315
OWN - NLM
STAT- MEDLINE
DCOM- 19961023
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 118
IP  - 2
DP  - 1995 Dec
TI  - Inhibition of PDGF- and TGF-beta 1-induced collagen synthesis, migration and 
      proliferation by tranilast in vascular smooth muscle cells from spontaneously 
      hypertensive rats.
PG  - 213-21
AB  - Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) 
      proliferate faster and are more sensitive to transforming growth factor-beta 1 
      (TGF-beta 1) than those of normotensive Wistar-Kyoto rats. We studied the in 
      vitro effects of tranilast, an anti-allergic drug, on the proliferation, 
      migration and extracellular matrix synthesis in the SHR-VSMC. There were many 
      inhibitory effects of tranilast (30-300 microM) on SHR-VSMC. One is the effect on 
      the proliferation stimulated with fetal bovine serum (FBS), TGF-beta 1 and 
      platelet-derived growth factor-BB (PDGF-BB). Another is the effect on the 
      PDGF-BB-induced migration. Lastly, tranilast exhibited inhibitory effects on 
      spontaneous collagen synthesis and TGF-beta 1-induced collagen and 
      glycosaminoglycan synthesis. On the other hand, collagen induced the VSMC 
      migration concentration-dependently. These results suggest that tranilast may 
      prevent restenosis after percutaneous transluminal coronary angioplasty.
FAU - Miyazawa, K
AU  - Miyazawa K
AD  - Pharmacological Laboratories, Kissei Pharmaceutical Co. Ltd., Nagano, Japan.
FAU - Kikuchi, S
AU  - Kikuchi S
FAU - Fukuyama, J
AU  - Fukuyama J
FAU - Hamano, S
AU  - Hamano S
FAU - Ujiie, A
AU  - Ujiie A
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Glycosaminoglycans)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (ortho-Aminobenzoates)
RN  - 9007-34-5 (Collagen)
RN  - HVF50SMY6E (tranilast)
SB  - IM
MH  - Angioplasty, Balloon, Coronary/adverse effects
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Arterial Occlusive Diseases/*prevention & control/therapy
MH  - Cell Division/drug effects
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Collagen/*biosynthesis
MH  - Drug Evaluation, Preclinical
MH  - Endothelium, Vascular/injuries
MH  - Extracellular Matrix/metabolism
MH  - Glycosaminoglycans/biosynthesis
MH  - Humans
MH  - Male
MH  - Muscle, Smooth, Vascular/*drug effects/metabolism
MH  - Platelet-Derived Growth Factor/*antagonists & inhibitors/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Recombinant Proteins/antagonists & inhibitors/pharmacology
MH  - Recurrence
MH  - Transforming Growth Factor beta/*antagonists & inhibitors/pharmacology
MH  - ortho-Aminobenzoates/*pharmacology
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 0021-9150(95)05607-6 [pii]
AID - 10.1016/0021-9150(95)05607-6 [doi]
PST - ppublish
SO  - Atherosclerosis. 1995 Dec;118(2):213-21. doi: 10.1016/0021-9150(95)05607-6.