PMID- 8770607
OWN - NLM
STAT- MEDLINE
DCOM- 19961023
LR  - 20210915
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 142
IP  - 1
DP  - 1996 Jan
TI  - A general Monte Carlo method for mapping multiple quantitative trait loci.
PG  - 305-11
AB  - In this paper we address the mapping of multiple quantitative trait loci (QTLs) 
      in line crosses for which the genetic data are highly incomplete. Such 
      complicated situations occur, for instance, when dominant markers are used or 
      when unequally informative markers are used in experiments with outbred 
      populations. We describe a general and flexible Monte Carlo 
      expectation-maximization (Monte Carlo EM) algorithm for fitting multiple-QTL 
      models to such data. Implementation of this algorithm is straightforward in 
      standard statistical software, but computation may take much time. The method may 
      be generalized to cope with more complex models for animal and human pedigrees. A 
      practical example is presented, where a three-QTL model is adopted in an 
      outbreeding situation with dominant markers. The example is concerned with the 
      linkage between randomly amplified polymorphic DNA (RAPD) markers and QTLs for 
      partial resistance to Fusarium oxysporum in lily.
FAU - Jansen, R C
AU  - Jansen RC
AD  - Centre for Plant Breeding and Reproduction Research, Wageningen, The Netherlands. 
      r.c.jansen@cpro.dlo.nl
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Chromosome Mapping/*methods/statistics & numerical data
MH  - Crosses, Genetic
MH  - Female
MH  - Fusarium/pathogenicity
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Models, Genetic
MH  - *Monte Carlo Method
MH  - Plants/genetics/microbiology
MH  - Random Amplified Polymorphic DNA Technique
PMC - PMC1206959
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
PMCR- 1996/04/01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PHST- 1996/04/01 00:00 [pmc-release]
AID - 1421305 [pii]
AID - 10.1093/genetics/142.1.305 [doi]
PST - ppublish
SO  - Genetics. 1996 Jan;142(1):305-11. doi: 10.1093/genetics/142.1.305.