PMID- 8773765
OWN - NLM
STAT- MEDLINE
DCOM- 19961125
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 718
IP  - 1-2
DP  - 1996 Apr 29
TI  - Effects of mianserin and ketanserin on lordosis behavior after systemic treatment 
      or infusion into the ventromedial nucleus of the hypothalamus.
PG  - 46-52
AB  - The effects of the 5-HT2A/2C antagonists, mianserin and ketanserin, were 
      investigated in proestrous rats and in ovariectomized rats hormonally primed with 
      estradiol benzoate and progesterone. Drugs were administered systemically or by 
      infusion into the vicinity of the ventromedial nucleus of the hypothalamus (VMN). 
      By both routes of administration, inhibition of lordosis behavior was seen 
      following treatment with the 5-HT2A/2C antagonists, but the magnitude of the 
      decline was smaller in proestrous than in hormone-primed, ovariectomized rats. 
      The results of these studies are discussed in terms of the dual role of serotonin 
      in the control of female sexual behavior.
FAU - Uphouse, L
AU  - Uphouse L
AD  - Department of Biology, Texas Woman's University, Denton 76204, USA.
FAU - Colon, L
AU  - Colon L
FAU - Cox, A
AU  - Cox A
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Wolf, A
AU  - Wolf A
LA  - eng
GR  - GM08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Serotonin Antagonists)
RN  - 250PJI13LM (Mianserin)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 97F9DE4CT4 (Ketanserin)
SB  - IM
MH  - Animals
MH  - Brain/anatomy & histology/drug effects
MH  - Estradiol/pharmacology
MH  - Female
MH  - Injections
MH  - Ketanserin/administration & dosage/*pharmacology
MH  - Male
MH  - Mianserin/administration & dosage/*pharmacology
MH  - Ovariectomy
MH  - Posture
MH  - Proestrus/physiology
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Antagonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Vagina/cytology
MH  - Ventromedial Hypothalamic Nucleus/*physiology
EDAT- 1996/04/29 00:00
MHDA- 1996/04/29 00:01
CRDT- 1996/04/29 00:00
PHST- 1996/04/29 00:00 [pubmed]
PHST- 1996/04/29 00:01 [medline]
PHST- 1996/04/29 00:00 [entrez]
AID - 0006-8993(96)00049-2 [pii]
AID - 10.1016/0006-8993(96)00049-2 [doi]
PST - ppublish
SO  - Brain Res. 1996 Apr 29;718(1-2):46-52. doi: 10.1016/0006-8993(96)00049-2.