PMID- 8774979 OWN - NLM STAT- MEDLINE DCOM- 19961204 LR - 20190516 IS - 0918-2918 (Print) IS - 0918-2918 (Linking) VI - 34 IP - 11 DP - 1995 Nov TI - Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia. PG - 1130-3 AB - We report a 47-year-old Japanese woman with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) combined with acute type adult T-cell leukemia (ATL). The susceptibility for HAM/TSP and acute type of ATL is hitherto explained by human leukocyte antigen (HLA) haplotype-linked immune responsiveness to HTLV-I. This patient's HLA (A24Cw1B54DR4DQ4/A24Cw3B51DR8DQ1) included a HAM-associated HLA haplotype. This suggests that HAM patients with HAM-associated HLA haplotype can also develop the acute type of ATL. FAU - Furukawa, Y AU - Furukawa Y AD - Third Department of Internal Medicine, Kagoshima University. FAU - Okadome, T AU - Okadome T FAU - Tara, M AU - Tara M FAU - Niina, K AU - Niina K FAU - Izumo, S AU - Izumo S FAU - Osame, M AU - Osame M LA - eng PT - Case Reports PT - Journal Article PL - Japan TA - Intern Med JT - Internal medicine (Tokyo, Japan) JID - 9204241 RN - 0 (HLA Antigens) SB - IM MH - Adult MH - Fatal Outcome MH - Female MH - HLA Antigens/*immunology MH - Haplotypes MH - Humans MH - Leukemia-Lymphoma, Adult T-Cell/*complications/immunology/pathology MH - Paraparesis, Tropical Spastic/*complications/*etiology/immunology/pathology EDAT- 1995/11/01 00:00 MHDA- 1995/11/01 00:01 CRDT- 1995/11/01 00:00 PHST- 1995/11/01 00:00 [pubmed] PHST- 1995/11/01 00:01 [medline] PHST- 1995/11/01 00:00 [entrez] AID - 10.2169/internalmedicine.34.1130 [doi] PST - ppublish SO - Intern Med. 1995 Nov;34(11):1130-3. doi: 10.2169/internalmedicine.34.1130.