PMID- 8775071
OWN - NLM
STAT- MEDLINE
DCOM- 19961018
LR  - 20161018
IS  - 0892-7790 (Print)
IS  - 0892-7790 (Linking)
VI  - 9
IP  - 6
DP  - 1995 Dec
TI  - Mechanisms of shockwave action in the human kidney.
PG  - 443-8
AB  - The effects on the human kidney parenchyma of high-energy shockwaves (HESW) with 
      different energy densities were examined. Kidneys of patients treated by radical 
      nephrectomy for renal cell carcinoma were perfused with cold HTK solution 
      immediately after nephrectomy and kept in hypothermia (8 degrees C) for a maximum 
      of 4 hours. The tumor-free parenchyma was treated with 2000 shocks at energy 
      outputs of 15 kV (16 MPa, 0.15 mJ/mm2), 17 kV (32 MPa, 0.25 mJ/mm2), 19 kV (50 
      MPa, 0.4 mJ/mm2), and 21 kV (65 MPa, 0.6 mJ/mm2) in an experimental 
      electromagnetic shockwave system (Siemens Co., Erlanger, Germany). Resulting 
      tissue effects were analyzed by histologic and immunohistochemical examinations 
      and confocal laser scanning microscopy. Different sensitivities of cell 
      components, blood vessels, and tubules were found. Laser scanning microscopy 
      revealed nuclear alterations in the vicinity of the focus up to a distance of 
      approximately 10 mm. Severe histologic changes were found in a smaller zone, 
      while immunohistochemistry studies revealed negative collagen IV staining in an 
      area of approximately 4 x 4 mm (all distances measured within the plane 
      perpendicular to the acoustic axis). From these results, it can be concluded that 
      HESW directly damage the tubules and the vascular system, which might explain the 
      clinical changes after extracorporeal shockwave lithotripsy in human patients. 
      The extent of these effects seems to be dependent on the applied energy.
FAU - Roessler, W
AU  - Roessler W
AD  - Urological Department, Hospital St. Josef, Regensburg, Germany.
FAU - Steinbach, P
AU  - Steinbach P
FAU - Seitz, R
AU  - Seitz R
FAU - Hofstaedter, F
AU  - Hofstaedter F
FAU - Wieland, W F
AU  - Wieland WF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Carcinoma, Renal Cell/surgery
MH  - Collagen/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney/chemistry/*pathology
MH  - Kidney Neoplasms/surgery
MH  - *Lithotripsy
MH  - Microscopy, Confocal
MH  - Nephrectomy
MH  - Treatment Outcome
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1089/end.1995.9.443 [doi]
PST - ppublish
SO  - J Endourol. 1995 Dec;9(6):443-8. doi: 10.1089/end.1995.9.443.