PMID- 8776416
OWN - NLM
STAT- MEDLINE
DCOM- 19961028
LR  - 20191101
IS  - 0964-1955 (Print)
IS  - 0964-1955 (Linking)
VI  - 32B
IP  - 4
DP  - 1996 Jul
TI  - The significance of epidermal growth factor receptor and matrix 
      metalloproteinase-3 in squamous cell carcinoma of the oral cavity.
PG  - 217-21
AB  - Surgical specimens from 65 patients with squamous cell carcinoma (SCC) of the 
      oral cavity were examined immunohistochemically. The clinicopathological 
      significance of the expression of epidermal growth factor receptor (EGFR) and 
      matrix metalloproteinase-3 (MMP-3) was assessed. Among the 65 tumours, 20(30.8%) 
      and 37(56.9%) tested positively for EGFR and MMP-3, respectively. A positive 
      correlation between the expression of EGFR and MMP-3 was found. The expression of 
      EGFR in oral SCCs was associated with an advanced T stage of the primary tumour, 
      an advanced pathological stage, and a high incidence of neck metastasis. In 
      addition, MMP-3 was primarily expressed at the advancing front of cancer with a 
      diffuse invasive mode. Thus, overexpression of MMP-3 was associated with an 
      advanced pathological stage, a diffuse invasive mode, and a high incidence of 
      neck metastasis. The analysis of MMP-3 expression is useful to evaluate the 
      pathological status of tumours. Because EGFR-overexpressed tumour should produce 
      larger amounts of MMP-3 in vivo, a close examination of oral SCC for expression 
      of EGFR and MMP-3 should be helpful to predict their malignant potential.
FAU - Kusukawa, J
AU  - Kusukawa J
AD  - Department of Oral and Maxillofacial Surgery, Kurume University School of 
      Medicine, Japan.
FAU - Harada, H
AU  - Harada H
FAU - Shima, I
AU  - Shima I
FAU - Sasaguri, Y
AU  - Sasaguri Y
FAU - Kameyama, T
AU  - Kameyama T
FAU - Morimatsu, M
AU  - Morimatsu M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Cancer B Oral Oncol
JT  - European journal of cancer. Part B, Oral oncology
JID - 9214373
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*chemistry/enzymology/pathology
MH  - ErbB Receptors/*analysis
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lymphatic Metastasis
MH  - Male
MH  - Matrix Metalloproteinase 3/*analysis
MH  - Middle Aged
MH  - Mouth Neoplasms/*chemistry/enzymology/pathology
MH  - Neck
MH  - Neoplasm Invasiveness
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1016/0964-1955(96)00016-4 [doi]
PST - ppublish
SO  - Eur J Cancer B Oral Oncol. 1996 Jul;32B(4):217-21. doi: 
      10.1016/0964-1955(96)00016-4.