PMID- 8777953
OWN - NLM
STAT- MEDLINE
DCOM- 19960917
LR  - 20190821
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 9
IP  - 2
DP  - 1996 Feb
TI  - Absence of relationship between degree of nonspecific and specific bronchial 
      responsiveness in occupational asthma due to platinum salts.
PG  - 211-6
AB  - There is evidence that bronchial responsiveness to allergen is quantitatively 
      correlated with bronchial responsiveness to nonspecific stimuli in subjects with 
      allergic asthma. This association has been questioned in occupational asthma due 
      to low molecular weight substances. It was the aim of this study to assess the 
      quantitative association of bronchial responsiveness to methacholine (MCh) and 
      platinum salts (Pt), in the form of hexachloroplatinic acid, in workers with 
      occupational asthma due to platinum salts. Fifty seven subjects with exposure to 
      Pt, work-related asthma, and a positive bronchial challenge with Pt, underwent 
      skin prick tests with Pt and bronchial challenge with MCh. Using the provocation 
      concentration causing a > or = 50% fall in specific airway conductance 
      (PC50sGaw(Pt)) as dependent variable, anamnestic data (period from first symptoms 
      to removal, period between removal from exposure and diagnosis, and smoking), 
      season of the investigation, skin prick tests with environmental allergens, total 
      immunoglobulin E (IgE), skin reactivity to Pt (Pt concentration causing a 2 mm 
      wheal), and PC50sGaw(MCh) were included as independent variables for regression 
      analysis. Fifty two subjects (91%) showed a PC50sGaw(MCh) < 8 mg.mL-1 (geometric 
      mean for all subjects 1.6 mg.mL-1). Responsiveness to Pt varied widely between 
      subjects (geometric mean of PC50sGaw 9 x 10-5 mol.L-1, range 2 x 10-7 to 10-2 
      mol.L-1). There was no univariate correlation between bronchial responsiveness to 
      MCh and Pt, but there was a correlation between skin reactivity to Pt and 
      PC50sGaw(Pt) (r = 0.6). This association could not be improved by considering 
      PC50sGaw(MCh), the period from first symptoms to removal, or the period between 
      removal from exposure and diagnosis. The parameters that showed the highest 
      (negative) associations with PC50sGaw(Pt) were skin reactivity to Pt and the 
      period between removal from exposure and diagnosis (r = 0.65). We conclude that 
      there is a moderate association between bronchial responsiveness to platinum 
      salts and skin reactivity to platinum salts. However, there is no association 
      between methacholine responsiveness and bronchial responsiveness to allergen in 
      occupational asthma due to platinum salts.
FAU - Merget, R
AU  - Merget R
AD  - Dept of Internal Medicine, University Hospital Bergmannsheil, Bochum, Germany.
FAU - Dierkes, A
AU  - Dierkes A
FAU - Rueckmann, A
AU  - Rueckmann A
FAU - Bergmann, E M
AU  - Bergmann EM
FAU - Schultze-Werninghaus, G
AU  - Schultze-Werninghaus G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Allergens)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (Platinum Compounds)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 16941-12-1 (chloroplatinic acid)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/adverse effects
MH  - Asthma/chemically induced/immunology/*physiopathology
MH  - Bronchial Hyperreactivity/chemically induced/immunology/*physiopathology
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Lung/physiopathology
MH  - Male
MH  - Methacholine Chloride
MH  - Middle Aged
MH  - Occupational Diseases/chemically induced/immunology/*physiopathology
MH  - Occupational Exposure/*adverse effects
MH  - Patch Tests
MH  - Platinum Compounds/*adverse effects
MH  - Regression Analysis
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1183/09031936.96.09020211 [doi]
PST - ppublish
SO  - Eur Respir J. 1996 Feb;9(2):211-6. doi: 10.1183/09031936.96.09020211.