PMID- 8778840 OWN - NLM STAT- MEDLINE DCOM- 19960913 LR - 20190712 IS - 0031-9384 (Print) IS - 0031-9384 (Linking) VI - 59 IP - 4-5 DP - 1996 Apr-May TI - Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference. PG - 597-604 AB - The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p < 0.05) increase (double) the seconds spent in their least-preferred chamber following cocaine-chamber pairings. Subsequently, groups of rats underwent one of three treatments: 1) olfactory bulbectomy (BULBX), 2) sham surgery (SHAM), or 3) sham surgery plus intranasal zinc sulfate perfusion (ZnSO4). Zinc sulfate was used to produce a temporary loss of olfaction. In a separate behavioral measure of olfactory acuity, both BULBX and ZnSO4-treated rats performed at an equally deficient level, in contrast to SHAM-treated rats that were not rendered anosmic. A second conditioned place preference test revealed that the ZnSO4-perfused and SHAM groups did not differ from their original postcocaine preference measurements. In contrast, the BULBX group spent significantly fewer seconds in the cocaine-paired chamber. After a 14-day interval, a third preference test revealed that SHAM and ZnSO4-treated rats displayed an equivalent preference for the cocaine-paired chamber (at 2.7 times above baseline). Interestingly, the seconds spent in the cocaine-paired chamber by BULBX rats did not differ from their baseline (e.g., precocaine exposure). These results suggest that bulbectomy disrupts the expression of cocaine-induced place preference. Interpretations of data from BULBX rats involving the production of an anhedonic condition and the relevance of olfactory bulbectomy as an animal model of anhedonic depression are discussed. FAU - Calcagnetti, D J AU - Calcagnetti DJ AD - Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-0095, USA. FAU - Quatrella, L A AU - Quatrella LA FAU - Schechter, M D AU - Schechter MD LA - eng GR - 8598/PHS HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 0 (Narcotics) RN - 0 (Sulfates) RN - 0 (Zinc Compounds) RN - 7733-02-0 (Zinc Sulfate) RN - I5Y540LHVR (Cocaine) SB - IM MH - Animals MH - Body Weight/drug effects/physiology MH - Cocaine/*pharmacology MH - Conditioning, Operant/*drug effects MH - Male MH - Narcotics/*pharmacology MH - Olfaction Disorders/psychology MH - Olfactory Bulb/anatomy & histology/*physiology MH - Rats MH - Reward MH - Smell/drug effects/*physiology MH - Sulfates/pharmacology MH - Zinc Compounds/pharmacology MH - Zinc Sulfate EDAT- 1996/04/01 00:00 MHDA- 1996/04/01 00:01 CRDT- 1996/04/01 00:00 PHST- 1996/04/01 00:00 [pubmed] PHST- 1996/04/01 00:01 [medline] PHST- 1996/04/01 00:00 [entrez] AID - 0031-9384(95)02119-1 [pii] AID - 10.1016/0031-9384(95)02119-1 [doi] PST - ppublish SO - Physiol Behav. 1996 Apr-May;59(4-5):597-604. doi: 10.1016/0031-9384(95)02119-1.