PMID- 8779959
OWN - NLM
STAT- MEDLINE
DCOM- 19961220
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 270
IP  - 2 Pt 1
DP  - 1996 Feb
TI  - Effects of fish oil on metabolic responses to oral fructose and glucose loads in 
      healthy humans.
PG  - E353-62
AB  - This study examines the effect of the substitution of 6 g/day of fish oil in a 
      saturated diet on glucose and fructose metabolism in healthy humans. Five 
      subjects were submitted to two 3-wk controlled-diet periods 
      (polyunsaturated/saturated = 0.21). During one period, 6 g/day of fat used for 
      dressing were replaced by 6 g/day of fish oil [1.1 g/day of 20:5 (n-3) fatty 
      acids and 0.7 g/day of 22:6 (n-3) fatty acids]. At the end of each period the 
      subjects ingested a 1 g/kg fructose or glucose load 2 days apart. Plasma glucose 
      fluxes were traced with the use of deuterated glucose and [U-13C]glucose. 
      Substrate oxidation was measured by indirect calorimetry. Fish oil induced a 4% 
      increase in basal and postload glycemia and a 40% decrease in insulinemia, 
      whereas plasma C-peptide remained unaffected. Glucose fluxes were unaffected by 
      fish oil, but carbohydrate (CHO) oxidation was reduced (fructose: 55.5 +/- 4.1 
      vs. 62.9 +/- 3.6 g/6 h; glucose: 36.7 +/- 4.7 vs. 50.5 +/- 4.7 g/6 h; all P < 
      0.05). Lipid oxidation was increased 35% by fish oil after both CHO loads. 
      Nonoxidative glucose disposal was increased by fish oil (fructose: 9.4 +/- 2.5 
      vs. 2.9 +/- 1.1 g/6 h; glucose: 28.3 +/- 5.1 vs. 14.4 +/- 4.7 g/6 h; all P < 
      0.05). Fish oil could affect glucose transport and decrease CHO oxidation through 
      the decrease in insulinemia and/or a specific effect on glycolytic pathway.
FAU - Delarue, J
AU  - Delarue J
AD  - Laboratoire de Nutrition et Jeune Equipe 313 Lipides et Croissance, Universite de 
      Tours, France.
FAU - Couet, C
AU  - Couet C
FAU - Cohen, R
AU  - Cohen R
FAU - Brechot, J F
AU  - Brechot JF
FAU - Antoine, J M
AU  - Antoine JM
FAU - Lamisse, F
AU  - Lamisse F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (C-Peptide)
RN  - 0 (Fish Oils)
RN  - 0 (Insulin)
RN  - 0 (Phospholipids)
RN  - 30237-26-4 (Fructose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Platelets/metabolism
MH  - C-Peptide/blood
MH  - Energy Metabolism
MH  - Female
MH  - Fish Oils/*pharmacology
MH  - Fructose/*metabolism
MH  - Glucose/*metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Oxidation-Reduction
MH  - Phospholipids/blood
MH  - Reference Values
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1152/ajpendo.1996.270.2.E353 [doi]
PST - ppublish
SO  - Am J Physiol. 1996 Feb;270(2 Pt 1):E353-62. doi: 10.1152/ajpendo.1996.270.2.E353.