PMID- 8780744
OWN - NLM
STAT- MEDLINE
DCOM- 19961016
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 90
IP  - 1
DP  - 1996 Aug
TI  - Complex cytogenetic and immunophenotypic aberrations in a patient with Sezary 
      syndrome.
PG  - 33-6
AB  - Sezary syndrome is defined as the leukemic variation of cutaneous T-cell 
      lymphomas. Here we describe the cytogenetic pattern of peripheral T-cells of a 
      50-year-old male patient suffering from this disease. We used Giemsa-banding 
      (G-banding) technique and a fluorescence in situ hybridization (FISH) assay to 
      determine cytogenetic changes affecting 15 different chromosomes. The cells 
      displayed an abnormal hypodiploid karyotype with a prominent insertion located at 
      the short arm of chromosome 1. Unbalanced translocations were observed involving 
      chromosomes 4 and 14. Besides other abnormalities we detected a 6q- deletion. 
      These multiple genetic changes may reflect the high aggressivity of the 
      neoplastically transformed T-cell population and the poor response to 
      chemotherapeutic treatment.
FAU - Mohr, B
AU  - Mohr B
AD  - Universitatsklinikum Carl Gustav Carus der Technischen Universitat Dresden, 
      Germany.
FAU - Illmer, T
AU  - Illmer T
FAU - Oelschlagel, U
AU  - Oelschlagel U
FAU - Nowak, R
AU  - Nowak R
FAU - Holig, K
AU  - Holig K
FAU - Paaz, U
AU  - Paaz U
FAU - Kroschinsky, F
AU  - Kroschinsky F
FAU - Schuler, U
AU  - Schuler U
FAU - Ehninger, G
AU  - Ehninger G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aneuploidy
MH  - CD4-Positive T-Lymphocytes/*pathology
MH  - CD8-Positive T-Lymphocytes/*pathology
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Fatal Outcome
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplastic Stem Cells/immunology/*pathology
MH  - Sezary Syndrome/*genetics/pathology
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0165460896000386 [pii]
AID - 10.1016/0165-4608(96)00038-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Aug;90(1):33-6. doi: 10.1016/0165-4608(96)00038-6.