PMID- 8780747
OWN - NLM
STAT- MEDLINE
DCOM- 19961016
LR  - 20211203
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 90
IP  - 1
DP  - 1996 Aug
TI  - Translocation (3;14)(q27;q11): a new variant translocation in a patient with 
      non-Hodgkin's lymphoma of B-cell type with BCL6 rearrangement.
PG  - 49-53
AB  - We report a 65-year-old woman with non-Hodgkin's lymphoma (NHL) carrying a 
      t(3;14)(q27;q11) and BCL6 rearrangement in the affected cells. She had 
      generalized lymphadenopathy and the bone marrow was infiltrated by lymphoma cells 
      at presentation. Histological diagnosis was "malignant lymphoma, diffuse, large 
      cell" type according to an International Working Formulation. Chromosome analysis 
      revealed a t(3;14)(q27;q11), which is a new variant translocation of t(3;14) 
      (q27;q32). Southern blot analysis showed rearrangement of BCL6, JH, and TCR beta 
      but not of TCR delta. Cosmid probe of BCL6 hybridized to 14q11 and 3q27 by 
      fluorescence in situ hybridization (FISH). Although the band 14q11 is a locus of 
      T-cell receptor alpha- and delta-chains (TCR alpha/delta), lymphoma cells 
      expressed B-cell, IgGk phenotype. The findings suggest that a novel 
      proto-oncogene in the vicinity of TCR alpha/delta is involved in this 
      translocation.
FAU - Takahashi, N
AU  - Takahashi N
AD  - Third Department of Internal Medicine, Akita University School of Medicine, 
      Japan.
FAU - Miura, I
AU  - Miura I
FAU - Ohshima, A
AU  - Ohshima A
FAU - Utsumi, S
AU  - Utsumi S
FAU - Nimura, T
AU  - Nimura T
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Cyubachi, A
AU  - Cyubachi A
FAU - Saitoh, M
AU  - Saitoh M
FAU - Enomoto, K
AU  - Enomoto K
FAU - Miki, T
AU  - Miki T
FAU - Hirosawa, S
AU  - Hirosawa S
FAU - Miura, A
AU  - Miura A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Aged
MH  - Antigens, Neoplasm/analysis
MH  - B-Lymphocytes/pathology
MH  - Bone Marrow/immunology/ultrastructure
MH  - Chromosomes, Human, Pair 14/genetics/*ultrastructure
MH  - Chromosomes, Human, Pair 3/genetics/*ultrastructure
MH  - DNA-Binding Proteins/genetics
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/pathology
MH  - Neoplastic Stem Cells/immunology/ultrastructure
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - *Proto-Oncogenes
MH  - Transcription Factors/genetics
MH  - *Translocation, Genetic
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0165460896000684 [pii]
AID - 10.1016/0165-4608(96)00068-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Aug;90(1):49-53. doi: 10.1016/0165-4608(96)00068-4.