PMID- 8780751
OWN - NLM
STAT- MEDLINE
DCOM- 19961016
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 90
IP  - 1
DP  - 1996 Aug
TI  - Double minutes in the papillary thyroid cancer cell line PTC-1113A.
PG  - 70-4
AB  - The cell line PTC-1113A was established from a metastasizing recurrent papillary 
      thyroid cancer. The cell line was growing as monolayer and showed a complex 
      karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion 
      of metaphases contained double minutes and/or pulverized chromosomes. 
      Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 
      4 painting probe hybridized to extrachromosomal material, representing double 
      minutes (dmin) and possibly minutes. In addition, fluorescence in situ 
      hybridization (FISH) with the chromosome 4 library detected a translocation 
      chromosome and a pulverized chromosome originating from chromosome 4. PTC-1113A 
      is, to our knowledge, the single papillary thyroid cancer cell line demonstrating 
      evidence of gene amplification.
FAU - Herrmann, M E
AU  - Herrmann ME
AD  - Department of Surgery and Pathology, SUNY at Stony Brook, USA.
FAU - Lalley, P A
AU  - Lalley PA
FAU - Rydstedt, L L
AU  - Rydstedt LL
FAU - Meese, E
AU  - Meese E
FAU - Lang, C H
AU  - Lang CH
FAU - Abumrad, N N
AU  - Abumrad NN
FAU - Moll, U M
AU  - Moll UM
FAU - Talpos, G B
AU  - Talpos GB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Carcinoma, Papillary/genetics/*pathology
MH  - Chromosomes, Human/ultrastructure
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasm Metastasis
MH  - Thyroid Neoplasms/genetics/*pathology
MH  - Tumor Cells, Cultured
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0165460896000489 [pii]
AID - 10.1016/0165-4608(96)00048-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Aug;90(1):70-4. doi: 10.1016/0165-4608(96)00048-9.