PMID- 8780753
OWN - NLM
STAT- MEDLINE
DCOM- 19961016
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 90
IP  - 1
DP  - 1996 Aug
TI  - Short arm of chromosome 1 aberration recurrently found in pigmented villonodular 
      synovitis.
PG  - 80-5
AB  - Pigmented villonodular synovitis (PVNS) is a relatively uncommon benign lesion 
      that is characterized by diffuse synovial proliferation, mainly occurring in knee 
      joints. Cytogenetic reports about this lesion are few and they describe the 
      presence of numerical and structural chromosome aberrations. We obtained PVNS 
      tissue from the left knee joint of a 53-year-old female, and performed 
      cytogenetic analysis. Fluorescence in situ hybridization (FISH) was also 
      performed by using the formalin fixed, paraffin embedded PVNS tissue. Two 
      seemingly unrelated clones were found: the first clone had structural 
      abnormalities of chromosome 1, 3, and 18, and the second one had trisomy 7 as a 
      sole numerical abnormality. FISH using a chromosome 7 specific alpha-satellite 
      DNA probe revealed that interphase nuclei possessed two or three signals. We 
      describe the clonal aberrations found in a case of PVNS. The deleted lesion of 
      the chromosome 1 (1p10-1p31.3) includes the locus of coagulation factor III gene 
      (1p22-p21), and the coagulation factor V (1q21-q25) locus includes another 
      breakpoint that is 1q25. In addition, recurrent structural abnormalities at the 
      short arm of chromosome 1 have been reported. These facts might play some role in 
      the hemorrhagic tendency and histogenesis of these lesions.
FAU - Ohjimi, Y
AU  - Ohjimi Y
AD  - Department of Pathology, Fukuoka University School of Medicine, Japan.
FAU - Iwasaki, H
AU  - Iwasaki H
FAU - Ishiguro, M
AU  - Ishiguro M
FAU - Kaneko, Y
AU  - Kaneko Y
FAU - Tashiro, H
AU  - Tashiro H
FAU - Emoto, G
AU  - Emoto G
FAU - Ogata, K
AU  - Ogata K
FAU - Kikuchi, M
AU  - Kikuchi M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 9001-24-5 (Factor V)
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1/*ultrastructure
MH  - Chromosomes, Human, Pair 7
MH  - Clone Cells/ultrastructure
MH  - Factor V/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Middle Aged
MH  - *Sequence Deletion
MH  - Synovitis, Pigmented Villonodular/*genetics
MH  - Thromboplastin/genetics
MH  - Trisomy
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0165460896000647 [pii]
AID - 10.1016/0165-4608(96)00064-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Aug;90(1):80-5. doi: 10.1016/0165-4608(96)00064-7.