PMID- 8781708
OWN - NLM
STAT- MEDLINE
DCOM- 19961209
LR  - 20131121
IS  - 0098-6127 (Print)
IS  - 0098-6127 (Linking)
VI  - 22
IP  - 1
DP  - 1996
TI  - Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human 
      monocytes in response to monocyte chemotactic protein 1.
PG  - 24-35
AB  - While estrogen is known to retard the development of atherosclerosis, the exact 
      mechanism is unknown. The migration of monocytes into the arterial intima is 
      important in the pathogenesis of atherosclerosis. Monocyte chemotactic protein 1 
      (MCP-1) is suggested to be a real chemotactic factor that is released from 
      monocytes, endothelial cells, and smooth muscle cells. We investigated the effect 
      of 17 beta-estradiol on the migration of human monocytes in response to MCP-1, 
      using a modified Boyden chamber. A physiological concentration of 17 
      beta-estradiol (10(12) - 10(4)M) inhibited the migration of monocytes exposed to 
      MCP-1. Two estrogen receptor antagonists, tamoxifen and clomiphene, each restored 
      monocyte chemotaxis to MCP-1 to control level, even in the presence of 17 
      beta-estradiol, suggesting that estrogen receptors are related to the effect of 
      17 beta-estradiol. Progesterone and testosterone had no measurable effect on 
      monocyte migration. These findings suggest that inhibition of the chemotactic 
      response of monocytes exposed to MCP-1 may be one mechanism for the 
      anti-atherogenic effect of 17 beta-estradiol.
FAU - Yamada, K
AU  - Yamada K
AD  - Department of Geriatrics, Nagoya University School of Medicine, Japan.
FAU - Hayashi, T
AU  - Hayashi T
FAU - Kuzuya, M
AU  - Kuzuya M
FAU - Naito, M
AU  - Naito M
FAU - Asai, K
AU  - Asai K
FAU - Iguchi, A
AU  - Iguchi A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Artery
JT  - Artery
JID - 7508494
RN  - 0 (Chemokine CCL2)
RN  - 3XMK78S47O (Testosterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Arteriosclerosis/physiopathology
MH  - Cells, Cultured
MH  - Chemokine CCL2/*antagonists & inhibitors/pharmacology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Estradiol/*pharmacology
MH  - Humans
MH  - Monocytes/drug effects
MH  - Progesterone/pharmacology
MH  - Testosterone/pharmacology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Artery. 1996;22(1):24-35.